Evidence map›Paper›PMID 39343853›Full record

ArticleAmino acids2024

HECTD2 as a target for veratric acid in the regulation of ferroptosis in renal cell carcinoma.

Dong Lv, Ying Xiang, Tao Song, Jinze Li, Yongbo Chen, Youlong Huili, Taimin Shen

Abstract read
In one paragraph

Article in Amino acids, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dong Lv *Department of Urology, Deyang People's Hospital, Deyang, 618000, China.
Ying Xiang *Department of Urology, School of Medicine, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Tao SongDepartment of Urology, School of Medicine, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
Jinze LiDepartment of Urology, Deyang People's Hospital, Deyang, 618000, China.
Yongbo ChenDepartment of Urology, Deyang People's Hospital, Deyang, 618000, China.
Youlong HuiliDepartment of Urology, Deyang People's Hospital, Deyang, 618000, China.
Taimin ShenDepartment of Health Management Center and, Institute of Health Management, School of Medicine, Sichuan Provincial People's Hospital, No. 32, West Second Section, 1St Ring Road, Qingyang District, Chengdu, 610072, China. taimshen@163.com.

Funding

Deyang People's Hospital 2023 Hospital Incubation Project FHS202301Science and Technology Bureau of Deyang City, Project Funding of Social Development 2023SZZ004Sichuan Provincial Key Chinese Culture Research Institute - Tibetan and Qiang Yi Culture Research Institute Key Project Funding ZQY2023ZX02
6 · The paper itself

Abstract

Function of HECTD2 in renal cell carcinoma malignant progression is undefined. Molecular mechanism behind anti-cancer effects of veratric acid (VA) from traditional Chinese medicine (TCM) is underexplored. The Cancer Genome Atlas was leveraged to study HECTD2 expression in renal cell carcinoma and its relationship with histological grading. Kaplan-Meier survival analysis was performed. HECTD2 expression was detected in cancer cells and tissues via qRT-PCR and immunohistochemistry. GPX4 and SLC7A11 expression in tumor samples with high or low HECTD2 expression was examined by immunohistochemistry, cell viability by CCK8, cell proliferation by colony formation assay, lipid ROS and mitochondrial superoxide levels by flow cytometry, Fe

Indexed as

Carcinoma, Renal CellFerroptosisKidney NeoplasmsAmino Acid Transport System y+AnimalsCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansMaleMiceMice, NudePhospholipid Hydroperoxide Glutathione PeroxidaseXenograft Model Antitumor AssaysAmino Acid Transport System y+Phospholipid Hydroperoxide Glutathione PeroxidaseSLC7A11 protein, humanFerroptosisHECTD2Renal cell carcinomaTraditional Chinese medicineVeratric acid

Identifiers

PMID39343853
PMCPMC11439856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.