Evidence map›Paper›PMID 39343816›Full record

ArticleScientific reports2024

Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate.

Chirakan Charoenvicha, Jirapan Thongsroy, Nattayaporn Apaijai, Tanawat Attachaipanich, Wimon Sirimaharaj, Krit Khwanngern, Nipon Chattipakorn, Apiwat Mutirangura, Siriporn C Chattipakorn

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chirakan CharoenvichaPlastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Jirapan ThongsroySchool of Medicine, Walailak University, Nakhon Si Thammarat, 80160, Thailand.
Nattayaporn ApaijaiNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Tanawat AttachaipanichNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Wimon SirimaharajPlastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Krit KhwanngernPlastic and Reconstructive Surgery Unit, Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Nipon ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
Apiwat MutiranguraCenter of Excellence in Molecular Genetics of Cancer & Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. mapiwat@chula.ac.th.
Siriporn C ChattipakornNeurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. siriporn.c@cmu.ac.th.

Funding

Chiang Mai University CMU Excellent Center awardNational Research Council of Thailand CCNational Research Council of Thailand N42A660301 (SC)National Research Council of Thailand NCNational Science and Technology Development Agency AM
6 · The paper itself

Abstract

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common craniofacial anomalies. Abnormal Alu methylation in DNA of the pregnant mother may influence the abnormal development of the child. This study aimed to examine Alu methylation and cellular senescence in NSCL/P patients and their mothers as well as the correlation with the severity of NSCL/P. A total of 39 patients with NSCL/P and 33 mothers were enrolled. Of these patients, 6 were cleft lip only (CLO), 9 were cleft palate only (CPO), and 24 were cleft lip and palate (CLP). Alu methylation and senescence markers were determined in the white blood cells of NSCL/P patients, their mothers, and in the lip and palatal tissues of patients at the time of cheiloplasty and palatoplasty. Total Alu methylation was not significantly different between groups. However, a decrease in Alu hypermethylation, increased partial Alu methylation, RAGE, and p16 expression were shown in CLP, the most severe cleft type. Alu methylation in tissues did not differ between groups. In mothers, an increase in Alu methylation was observed only in the CLP. Therefore, the pathogenesis of NSCL/P may be related to Alu methylation of the mother promoting loss of Alu methylation and subsequently senescence in the children.

Indexed as

Alu ElementsCellular SenescenceCleft LipCleft PalateDNA MethylationAdultBiomarkersChildChild, PreschoolFemaleHumansInfantMalePregnancyBiomarkersAging processAlu methylationCellular senescenceCleft lip and palateDNA methylationOxidative stress

Identifiers

PMID39343816
PMCPMC11439953

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.