ArticleJournal of clinical and experimental hematopathology : JCEH2024
TTMV::RARA-positive acute promyelocytic leukemia with marrow necrosis and central nervous system involvement at disease recurrence.
Article in Journal of clinical and experimental hematopathology : JCEH, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The comprehensive landscape ofHaematologica · 2026Article
- Article
- Case report:Frontiers in oncology · 2026Article
- Acute promyelocytic leukemia with a novel TTMV::RARA fusion initially presenting as vertebral myeloid sarcoma: a case report.Frontiers in oncology · 2026Article
- Clinical features and fusion gene analysis of two Torque Teno Mini virus associated acute promyelocytic leukemia cases.Annals of hematology · 2025Article
- Identification and visualization of fusion gene subtypes in APL using spatial attention mechanisms in vision models.Frontiers in oncology · 2025Article
- Review
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6 authors.
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Abstract
Since the identification of the TTMV::RARA fusion in pediatric cases resembling acute promyelocytic leukemia (APL) by Astolfi et al. in 2021, several similar cases have been reported worldwide. In this report, we present a case of relapsed APL in an adolescent patient, who exhibited the TTMV::RARA fusion gene. This patient exhibited extensive central nervous system involvement and experienced bone marrow necrosis during disease recurrence. Despite achieving complete remission after re-induction chemotherapy, the patient experienced a rapid second relapse, highlighting the extremely aggressive nature of this subtype. These clinical manifestations contribute to the growing recognition of this rare disease.
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