Evidence map›Paper›PMID 39343572›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Glioblastoma Arising in Lynch-like Syndrome after Repeated Development of Colorectal Cancers.

Ayako Togawa, Masayuki Ueno, Mari Yamaoka, Kensuke Takada, Shinichi Nishina, Yuki Ikeda, Yosuke Uenishi, Ayako Hata, Toshifumi Mano, Toshikazu Moriwaki and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ayako TogawaDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Masayuki UenoDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Mari YamaokaDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Kensuke TakadaDepartment of Neurosurgery, Kurashiki Central Hospital, Japan.
Shinichi NishinaDepartment of Medical Oncology, Kurashiki Central Hospital, Japan.
Yuki IkedaDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Yosuke UenishiDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Ayako HataDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Toshifumi ManoDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Toshikazu MoriwakiDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Hirokazu MouriDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.
Motowo MizunoDepartment of Gastroenterology and Hepatology, Kurashiki Central Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We herein report a patient with Lynch-like syndrome in whom a brain tumor (glioblastoma) developed after repeated resection of colorectal cancer. The patient had a significant family history of cancer. Immunohistochemical expression of mismatch repair proteins was decreased in both brain and colon tumors, but no pathogenic variant of the related genes was detected. Although brain tumors occasionally develop in Lynch syndrome, they have not been reported in cases of Lynch-like syndrome. This first report of Lynch-like syndrome with the development of glioblastoma suggests the need for further investigation on the surveillance of brain tumors in patients with this syndrome.

Indexed as

Brain NeoplasmsColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisGlioblastomaHumansbrain tumorhereditary nonpolyposis colorectal cancermismatch repair deficiencyTurcot syndrome

Identifiers

PMID39343572
PMCPMC12097828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.