Cryptogenic New-onset Refractory Status Epilepticus with Hyperintensity of T1-weighted Magnetic Resonance Imaging in the Bilateral Basal Ganglia: An Autopsy Report.

Sunao Takahashi, Daisuke Ono, Hiroshi Shintaku, Jun Oyama, Yoichiro Nishida, Kinya Ishikawa, Takanori Yokota

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Sunao TakahashiDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.

Daisuke OnoDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.

Hiroshi ShintakuDivision of Surgical Pathology, Tokyo Medical and Dental University Hospital, Japan.

Jun OyamaDepartment of Diagnostic Radiology and Nuclear Medicine, Tokyo Medical and Dental University, Japan.

Yoichiro NishidaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.

Kinya IshikawaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.

Takanori YokotaDepartment of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a 76-year-old man with cryptogenic new-onset refractory status epilepticus (C-NORSE) with an initial abnormal signal in the nucleus accumbens and a remarkable hyperintense signal on T1-weighted magnetic resonance imaging in the bilateral basal ganglia (BG). His status epilepticus did not respond to most anti-epileptic therapies or immunotherapies, and he died of sepsis. An autopsy revealed severe neuronal loss and hypertrophic astrocytes in the BG and limbic system, with no signs of inflammation or malignancy. This case suggests that lesions in the BG may reflect secondary degeneration and predict poor outcomes in C-NORSE.

Indexed as

Basal GangliaMagnetic Resonance ImagingStatus EpilepticusAgedAutopsyFatal OutcomeHumansMalebasal gangliacryptogenic new-onset refractory status epilepticusgliosisneuronal lossnucleus accumbenspathology

Identifiers

PMID39343569

DOI10.2169/internalmedicine.4217-24

PMCPMC12120234

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