Evidence map›Paper›PMID 39343106›Full record

ArticleBrain, behavior, and immunity2025

Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb).

Yool Lee, Erika L English, Catherine M Schwartzmann, Yiyong Liu, James M Krueger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yool LeeDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA; Sleep and Performance Research Center, Washington State University, Spokane, WA 99202, USA; Steve Gleason Institute for Neuroscience, Washington State University, Spokane, WA 99202, USA. Electronic address: yool.lee@wsu.edu.
Erika L EnglishSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA.
Catherine M SchwartzmannDepartment of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Yiyong LiuDepartment of Translational Medicine and Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA; Genomics Core, Washington State University, Spokane, WA, USA.
James M KruegerSchool of Molecular Biosciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99163, USA; Department of Integrative Physiology and Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA. Electronic address: j.krueger@wsu.edu.

Funding

INTERLEUKIN-1--PROMOTER OF SLOW-WAVE SLEEPR01NS025378 · NINDS · WASHINGTON STATE UNIVERSITY · PI KRUEGER, JAMES MARTIN · 1987 to 2020
$6.3M
NINDS NIH HHS R01 NS025378
6 · The paper itself

Abstract

Interleukin-1β (IL1), a pleiotropic cytokine, is involved in sleep regulation, tumor ontogeny, and immune responses. IL1 receptor adaptor proteins, including the IL1 receptor accessory protein (AcP), and its neuron-specific isoform, AcPb, are required for IL1 signaling. The AcPb isoform is resultant from alternate splicing of the AcP transcript. Our previous studies using AcPb null (AcPb

Indexed as

Interleukin-1 Receptor Accessory ProteinMice, KnockoutNeuronsSleep DeprivationAnimalsBrain NeoplasmsCarcinogenesisHumansInterleukin-1betaMaleMiceMice, Inbred C57BLSignal TransductionInterleukin-1betaInterleukin-1 Receptor Accessory ProteinAcPAcPbCancerGBMIL17IL1RAPIL1βLcn2LGGSleep disruptionTCGA

Identifiers

PMID39343106
PMCPMC11624092

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.