ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2024
Understanding metabolic diversification in plants: branchpoints in the evolution of specialized metabolism.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Nitrogen Status Rewires Transcriptional Regulation of Dhurrin, a Dual-Purpose Defense Metabolite inPlant direct · 2026Article
- Specialized Metabolic Reprogramming in Plant Immunity: Biosynthetic Networks, Spatiotemporal Regulation, and Quantitative Defense.Plants (Basel, Switzerland) · 2026Review
- Gas Chromatography-Mass Spectrometry (GC-MS) in the Plant Metabolomics Toolbox: GC-MS in Multi-Platform Metabolomics and Integrated Multi-Omics Research.International journal of molecular sciences · 2026Review
- A cell-type-specific regulon controlling monoterpene indole alkaloid biosynthesis with feedback and feedforward activation loops.The New phytologist · 2026Article
- Herbgenomics: Unraveling natural product biosynthesis in traditional Chinese medicine.Chinese herbal medicines · 2026Article
- Metabolite-based resistance in wheat varieties to aphid virus vectors: progress and future opportunities.Pest management science · 2025Review
- A million shades of green: understanding and harnessing plant metabolic diversity.The EMBO journal · 2025Review
- Engineering Gypsophila elegans hairy root cultures to produce endosomal escape-enhancing saponins.Plant biotechnology journal · 2025Article
- From data to discovery: leveraging big data in plant natural products biosynthesis research.The Plant journal : for cell and molecular biology · 2025Review
- Plant Secondary Metabolites-Central Regulators Against Abiotic and Biotic Stresses.Metabolites · 2025Review
- Integrated metabolomic and transcriptomic analysis reveals the biosynthesis mechanism of dihydrochalcones in sweet tea (Frontiers in plant science · 2025Article
- Australian Rainforests-A Living Museum of Natural Product Chemical Diversity.Progress in the chemistry of organic natural products · 2025Review
- Genome-wide identification and expression profiling ofFrontiers in plant science · 2025Article
- Localization of Secondary Metabolites in Relict Gymnosperms of the GenusLife (Basel, Switzerland) · 2024Article
- Current and future perspectives for enhancing our understanding of the evolution of plant metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
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3 authors.
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Abstract
Plants are chemical engineers par excellence. Collectively they make a vast array of structurally diverse specialized metabolites. The raw materials for building new pathways (genes encoding biosynthetic enzymes) are commonly recruited directly or indirectly from primary metabolism. Little is known about how new metabolic pathways and networks evolve in plants, or what key nodes contribute to branches that lead to the biosynthesis of diverse chemicals. Here we review the molecular mechanisms underlying the generation of biosynthetic branchpoints. We also consider examples in which new metabolites are formed through the joining of precursor molecules arising from different biosynthetic routes, a scenario that greatly increases both the diversity and complexity of specialized metabolism. Given the emerging importance of metabolic gene clustering in helping to identify new enzymes and pathways, we further cover the significance of biosynthetic gene clusters in relation to metabolic networks and dedicated biosynthetic pathways. In conclusion, an improved understanding of the branchpoints between metabolic pathways will be key in order to be able to predict and illustrate the complex structure of metabolic networks and to better understand the plasticity of plant metabolism. This article is part of the theme issue 'The evolution of plant metabolism'.
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