Evidence map›Paper›PMID 39343024›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2024

Plant sesquiterpene lactones.

Olivia Agatha, Daniela Mutwil-Anderwald, Jhing Yein Tan, Marek Mutwil

Abstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Molecular insights into volatile organic compound sensing and signaling in plants.The Plant journal : for cell and molecular biology · 2026
    Review
  4. Article
  5. Hemistepsin A induces apoptosis by modulating the reactive oxygen species-dependent PI3K/Akt signaling pathway in human lung carcinoma A549 cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  6. Article
  7. Furanoheliangolides fromJournal of natural products · 2025
    Article
  8. Exploring Sesquiterpene Lactones fromPlants (Basel, Switzerland) · 2025
    Article
  9. Article
  10. Current and future perspectives for enhancing our understanding of the evolution of plant metabolism.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olivia AgathaSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive , Singapore 637551, Singapore.
Daniela Mutwil-AnderwaldSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive , Singapore 637551, Singapore.
Jhing Yein TanSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive , Singapore 637551, Singapore.
Marek MutwilSchool of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive , Singapore 637551, Singapore.ORCID 0000-0002-7848-0126

Funding

Singaporean Ministry of Education
6 · The paper itself

Abstract

Sesquiterpene lactones (STLs) are a prominent group of plant secondary metabolites predominantly found in the Asteraceae family and have multiple ecological roles and medicinal applications. This review describes the evolutionary and ecological significance of STLs, highlighting their roles in plant defence mechanisms against herbivory and as phytotoxins, alongside their function as environmental signalling molecules. We also cover the substantial role of STLs in medicine and their mode of action in health and disease. We discuss the biosynthetic pathways and the various modifications that make STLs one of the most diverse groups of metabolites. Finally, we discuss methods for identifying and predicting STL biosynthesis pathways. This article is part of the theme issue 'The evolution of plant metabolism'.

Indexed as

LactonesSesquiterpenesAsteraceaeBiosynthetic PathwaysPlantsLactonesSesquiterpenesbioinformaticsbiosynthesismedicinalplantssesquiterpenespecialized metabolism

Identifiers

PMID39343024
PMCPMC11449222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.