Evidence map›Paper›PMID 39342891›Full record

ArticleBioorganic chemistry2024

Simplified scalable synthesis of a water-soluble toll-like receptor 2 agonistic lipopeptide adjuvant for use with protein-based viral vaccines.

Deshkanwar S Brar, Arshpreet Kaur, Madhuri T Patil, Yoshikazu Honda-Okubo, Nikolai Petrovsky, Deepak B Salunke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Deshkanwar S BrarDepartment of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India; National Interdisciplinary Centre of Vaccine Immunotherapeutics and Antimicrobials, Panjab University, Chandigarh 160014, India.
Arshpreet KaurDepartment of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India.
Madhuri T PatilDepartment of Chemistry, Mehr Chand Mahajan DAV College for Women, Chandigarh 160036, India.
Yoshikazu Honda-OkuboVaxine Pty Ltd, 11 Walkley Avenue, Warradale, South Australia 5046, Australia; Australian Respiratory and Sleep Medicine Institute, Bedford Park, South Australia 5042, Australia.
Nikolai PetrovskyVaxine Pty Ltd, 11 Walkley Avenue, Warradale, South Australia 5046, Australia; Australian Respiratory and Sleep Medicine Institute, Bedford Park, South Australia 5042, Australia; National Interdisciplinary Centre of Vaccine Immunotherapeutics and Antimicrobials, Panjab University, Chandigarh 160014, India. Electronic address: nikolai.petrovsky@vaxine.net.
Deepak B SalunkeDepartment of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India; National Interdisciplinary Centre of Vaccine Immunotherapeutics and Antimicrobials, Panjab University, Chandigarh 160014, India. Electronic address: salunke@pu.ac.in.

Funding

NIAID NIH HHS HHSN272201400053C
6 · The paper itself

Abstract

Toll-like receptors (TLRs) form a key bridge between the innate and adaptive immune systems. The lipopeptide based TLR2 agonists such as Pam

Indexed as

Adjuvants, ImmunologicLipopeptidesSolubilityToll-Like Receptor 2WaterAnimalsCOVID-19 VaccinesFemaleHumansMiceMice, Inbred BALB CMolecular StructureSARS-CoV-2Viral VaccinesAdjuvants, ImmunologicCOVID-19 VaccinesLipopeptidesToll-Like Receptor 2Viral VaccinesWaterAdjuvantCOVID-19LipopeptidePam(2)CSK(4)TLR2Vaccine

Identifiers

PMID39342891
PMCPMC11614683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.