Evidence map›Paper›PMID 39342819›Full record

ArticleJournal of chromatography. B, Analytical technologies in the biomedical and life sciences2024

Faster liquid chromatography-tandem mass spectrometry method for analysis of isomeric urinary mercapturic acid metabolites of crotonaldehyde, methacrolein, and methyl vinyl ketone.

Menglan Chen, Steven G Carmella, Yingchun Zhao, Stephen S Hecht

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Menglan ChenMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-148 CCRB, Minneapolis, MN 55455, USA.
Steven G CarmellaMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-148 CCRB, Minneapolis, MN 55455, USA.
Yingchun ZhaoMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-148 CCRB, Minneapolis, MN 55455, USA.
Stephen S HechtMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, 2-148 CCRB, Minneapolis, MN 55455, USA. Electronic address: hecht002@umn.edu.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and CarcinogensR01CA222005 · NCI · UNIVERSITY OF MINNESOTA · PI HATSUKAMI, DOROTHY K, HECHT, STEPHEN S · 2018 to 2022
$3.1M
High resolution mass spectrometric profile analysis of carcinogen-DNA adducts in oral cells of cigarette smokers and squamous cell carcinoma of the head and neckR01CA263084 · NCI · UNIVERSITY OF MINNESOTA · PI HECHT, STEPHEN S, KHARIWALA, SAMIR S · 2021 to 2025
$3.1M
Mass Spectrometric Analytical Collaborations with Members of the Masonic Cancer Center of the University of MinnesotaR50CA211256 · NCI · UNIVERSITY OF MINNESOTA · PI Peter William Villalta · 2016 to 2026
$2.1M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA222005NCI NIH HHS R01 CA263084NCI NIH HHS R50 CA211256
6 · The paper itself

Abstract

We report a significantly more rapid method for quantitation of the urinary mercapturic acids of the isomeric toxicants crotonaldehyde, methacrolein, and methyl vinyl ketone. The major innovation of this novel method is detection by liquid chromatography-negative atmospheric pressure chemical ionization-tandem mass spectrometry-selected reaction monitoring as opposed to detection by negative electrospray ionization in our previously reported method. The new method also uses an improved Raptor Biphenyl HPLC column. The total chromatographic analysis time was reduced to about 8 min compared to 35 min in our previously published method. Accuracy, precision, and ruggedness of the new method were established, and its suitability for the analysis of urine samples from 2500 cigarette smokers and non-smokers was confirmed. The improved method is practical for quantitation of these important toxicants in clinical studies requiring analysis of thousands of urine samples.

Indexed as

AcetylcysteineAcroleinAldehydesButanonesTandem Mass SpectrometryChromatography, High Pressure LiquidChromatography, LiquidHumansIsomerismLimit of DetectionLinear ModelsReproducibility of Results2-butenal3-buten-2-oneAcetylcysteineAcroleinAldehydesButanonesmethacrylaldehydeCrotonaldehydeLiquid chromatographyMethacroleinMethyl vinyl ketoneTandem mass spectrometryUrinary mercapturic acids

Identifiers

PMID39342819
PMCPMC11656938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.