Evidence map›Paper›PMID 39342592›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

In Vivo Detection of Multidrug-Resistance Related Proteins in Locally Advanced Breast Cancer Using 99mTc-MIBI SPECT/CT Imaging: Correlation with Clinical Outcomes.

Nadia M Mostafa, Maha S Elnaggar, Yasser G Abdelhafez, Khalid Rezk, Mahmoud Farouk Sherif, Hanan A Eltyb, Shaimaa Ahmed, Nagm Eldin Abu Elnga, Marwa T Hussien

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadia M MostafaDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Egypt.
Maha S ElnaggarDepartment of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University, Egypt.
Yasser G AbdelhafezDepartment of Radiation Oncology and Nuclear Medicine, South Egypt cancer institute, Assuit University, Egypt.
Khalid RezkDepartment of Surgical Oncology, South Egypt cancer institute, Assuit University, Egypt.
Mahmoud Farouk SherifDepartment of Pathology, Faculty of medicine, Assuit University, Egypt.
Hanan A EltybDepartment of Medical Oncology and Malignant Hematology, South Egypt cancer institute, Assuit University, Egypt.
Shaimaa AhmedDepartment of Radiation Oncology and Nuclear Medicine, South Egypt cancer institute, Assuit University, Egypt.
Nagm Eldin Abu ElngaGeneral Surgery Department, Faculty of Medicine, Assiut University, Egypt.
Marwa T HussienDepartment of Oncologic Pathology, South Egypt Cancer Institute, Assiut University, Egypt.ORCID 0000-0001-8561-8501

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNeoadjuvant chemotherapy (NACT) is widely used for treating locally advanced Breast cancer (LABC). However, development of multidrug resistance (MDR) is the main underlying factor for chemoresistance. Technetium-99m methoxyisobutylisonitrile (99mTc-MIBI) is a substrate for MDR. This study aimed to analyze the relationship between expression of MDR-related proteins (P-gp and Bcl-2) and 99mTc-MIBI uptake and retention in BC tumor cells, pathologic response to NACT, disease free survival (DFS) and overall survival (OS).

methodsprospective analysis recruited 31 patients with LABC who received NACT between January 2019 and March 2020. 99mTc-MIBI planar and SPECT/CT imaging was conducted before and after NACT. Qualitative and quantitative analyses were performed, pre and post-NACT early and delayed lesion to non-lesion (LNL) ratios, and retention index (RI) of 99mTc-MIBI were calculated. Expression of P-gp and Bcl-2 in tumor cells was determined by immunohistochemistry.

resultsQuantitively, inter-reader ICC for SPECT/CT based quantification was consistently higher than that of planar images. Post-NACT LNL ratios were significantly higher in patients with pathologic persistent disease (PPD). A change in RI between pre- and post-NACT scans demonstrated a significant association with DFS with a hazard ratio of 0.7 (95%CI: 06-1.0). Qualitatively, SPECT/CT was significantly more accurate compared to planar imaging in identifying residual viable tumor (81% compared to 57%).  Her2neu positivity and high post-operative Bcl-2 and P-gp were associated with worse DFS. A significant association was found between increased expression of post-NACT Bcl-2 and PPD, advanced tumor stage and poor OS.

conclusion99mTc-MIBI SPECT/CT based qualitative evaluation of BC response to NACT is more accurate than planar imaging. Post-NACT MIBI retention is positively correlated with P-gp and Bcl-2 expression. 99mTc-MIBI SPECT/CT may predict MDR development. High post-NACT Bcl-2 expression is significantly associated with advanced tumor stage and OS. High post-NACT P-gp expression has a worse impact on pathologic response and DFS.

Indexed as

Breast NeoplasmsRadiopharmaceuticalsSingle Photon Emission Computed Tomography Computed TomographyTechnetium Tc 99m SestamibiAdultAgedATP Binding Cassette Transporter, Subfamily B, Member 1Biomarkers, TumorDrug Resistance, MultipleDrug Resistance, NeoplasmFemaleFollow-Up StudiesHumansMiddle AgedNeoadjuvant TherapyPrognosisATP Binding Cassette Transporter, Subfamily B, Member 1BCL2 protein, humanBiomarkers, TumorProto-Oncogene Proteins c-bcl-2RadiopharmaceuticalsTechnetium Tc 99m Sestamibi99mTc-MIBI SPECT/CTBCL2breast cancerPgpsurvival

Identifiers

PMID39342592
PMCPMC11700319

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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.