Evidence map›Paper›PMID 39342575›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Ultrastructure Microscopic Characterization of Apoptosis in Myelomoncytic Leukemia Cell Line Treated with Velogenic Viscerotropic Newcastle Disease Virus Strain AF 2240.

Rola Ali-Saeed, Aied M Alabsi, Maged A Al-Garadi, Siddig Ibrahim Abdelwahab, Antony V Samrot, Vetriselvan Subramaniyan, Ismail Muhamad Fareez

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Alcohol-induced structural and cellular brain alterations: molecular and histopathological mechanisms.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rola Ali-SaeedDepartment of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Aied M AlabsiDepartment of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.
Maged A Al-GaradiAnimal Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
Siddig Ibrahim AbdelwahabHealth Research Centre, Jazan University, Jazan, Saudi Arabia.
Antony V SamrotDepartment of Microbiology, Faculty of Medicine, Manipal University College, Jalan Padang Jambu, Bukit Baru, Melaka, Malaysia.
Vetriselvan SubramaniyanPharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Selangor, Malaysia.
Ismail Muhamad FareezDepartment of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, Malaysia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLeukemia is a group of hematologic malignancies in the bonemarrow that arise from the dysfunctional proliferation of developing leukocytes. It is classified as either acute or chronic based on the rapidity of proliferation and as myelocytic or lymphocytic based on the cell of origin. Newcastle Disease Virus (NDV) is an avian paramyxovirus, which has been demonstrated to possess significant oncolytic activity against mammalian cancers because its ability to kill tumor cells with limited toxicity to normal cells.

methodsIn this study, the morphophical changes and apoptosis induction of WEHI 3B leukemia cell line treated with NDV strain AF2240 were studied by scanning electron microscopes and  transmission electron microscopes techniques.

resultElectron microscopy indicated that NDV strain AF 2240 significantly altered cell morphology and reduced cell viability. Furthermore,  early apoptosis was observed 6 h post-inoculation by fluorescence microscope.

conclusionOur results suggest that NDV has ability to induce significant apoptoic structural changes in WEHI 3B leukemia cell line. These findings provide new insights into the mechanism of action of NDV virotherapy and could lead to the development of more effective treatments for leukemia.

Indexed as

ApoptosisNewcastle disease virusAnimalsCell Line, TumorCell ProliferationHumansMiceMicroscopy, Electron, TransmissionOncolytic VirotherapyTumor Cells, CulturedApoptosisNDV strain AF 2240scanning electron microscopestransmission electron microscopes

Identifiers

PMID39342575
PMCPMC11700348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.