Evidence map›Paper›PMID 39342531›Full record

ArticleDrugs & aging2024

Prevalence of Adverse Drug Reactions in Hospital Among Older Patients with and Without Dementia.

Marissa A Sakiris, Sarah N Hilmer, Mouna J Sawan, Sarita Lo, Patrick J Kelly, Fiona M Blyth, Andrew J McLachlan, Danijela Gnjidic

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In one paragraph

Article in Drugs & aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marissa A Sakiris *Kolling Institute, The University of Sydney and Northern Sydney Local Health District, Royal North Shore Hospital, Sydney, NSW, Australia.ORCID 0000-0001-5410-3601
Sarah N Hilmer *Kolling Institute, The University of Sydney and Northern Sydney Local Health District, Royal North Shore Hospital, Sydney, NSW, Australia.ORCID 0000-0002-5970-1501
Mouna J SawanSydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-0565-3524
Sarita LoKolling Institute, The University of Sydney and Northern Sydney Local Health District, Royal North Shore Hospital, Sydney, NSW, Australia.ORCID 0000-0002-5272-9958
Patrick J KellySydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-5015-0977
Fiona M BlythSydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-1128-6756
Andrew J McLachlanSydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0003-4674-0242
Danijela GnjidicSydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia. danijela.gnjidic@sydney.edu.au.ORCID 0000-0002-9404-3401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder inpatients with dementia are at an increased risk of an adverse drug reaction (ADR) during hospitalization.

objectiveTo quantify the prevalence of ADRs in older inpatients according to dementia status and ADR definition approach and to identify risk factors of ADRs during hospitalization.

methodsThis was a retrospective cohort study of 2000 inpatients aged ≥ 75 years admitted consecutively to six Sydney hospitals (1 July 2016 to 31 May 2017). Dementia was defined by diagnosis in electronic medical records. ADRs were defined according to two approaches: the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM) and classification by a research pharmacist (subset cohort, n = 600). A binary logistic regression was conducted to determine risk factors of ADRs.

resultsAmong 2000 patients, 25.9% (n = 517) were reported to have dementia. ADRs defined by ICD-10-AM were identified in 8.3% (n = 43) and 14.6% (n = 217) of inpatients with and without dementia respectively (p < 0.001). A total of 13.0% (n = 260) and 12.5% (n = 75) of patients had ADRs defined by ICD-10-AM and a research pharmacist, respectively. Key risk factors of ADRs were longer hospital stay [odds ratio (OR) 1.01, 95% confidence interval (CI) 1.01, 1.02) and a greater number of regular potentially inappropriate medicines (PIMs) on admission (OR 1.17, 95% CI 1.00, 1.38).

conclusionsADRs were more prevalent among inpatients without dementia and when assessed by a research pharmacist. Our findings underline the need for improved ADR detection in older inpatients.

Indexed as

DementiaDrug-Related Side Effects and Adverse ReactionsHospitalizationAgedAged, 80 and overFemaleHumansMalePrevalenceRetrospective StudiesRisk Factors

Identifiers

PMID39342531
PMCPMC11480104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.