Evidence map›Paper›PMID 39342394›Full record

ReviewJournal of medical case reports2024

Asymptomatic thrombocytopenia after nintedanib initiation in a patient with progressive pulmonary fibrosis: a case report and review of literature.

Xinxin Zhang, Kan Zhang, Nannan Zhao, Na Xi, Tiemei Zhao

Abstract readCase ReportsReview
In one paragraph

Review in Journal of medical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinxin ZhangCollege of Pulmonary and Critical Care Medicine, the 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Kan ZhangCollege of Pulmonary and Critical Care Medicine, the 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Nannan ZhaoCollege of Pulmonary and Critical Care Medicine, the 8th Medical Center of Chinese PLA General Hospital, Beijing, China.
Na XiDepartment of Pharmacy, Chinese PLA General Hospital, Beijing, China.
Tiemei ZhaoCollege of Pulmonary and Critical Care Medicine, the 8th Medical Center of Chinese PLA General Hospital, Beijing, China. ztm1111@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNintedanib is a primary antifibrosing medication available for idiopathic pulmonary fibrosis, systemic sclerosis-interstitial lung disease, and progressive pulmonary fibrosis, with scattered report of drug-induced thrombocytopenia. CASE REPORT: A 60-year-old Asian male with no history of thrombocytopenia was administered with nintedanib to treat progressive pulmonary fibrosis. The platelet count dropped rapidly after introduction of nintedanib and resolved gradually by withdrawal of the medication along with thrombopoietin receptor agonist.

conclusionBased on experience from the limited reports, nintedanib-induced thrombocytopenia is typically reversible and manageable. Close monitoring of platelet counts in patients receiving this medication should be warranted.

Indexed as

IndolesThrombocytopeniaHumansIdiopathic Pulmonary FibrosisMaleMiddle AgedPlatelet CountPulmonary FibrosisIndolesnintedanibAnti-Mi-2 antibodyCase reportDrug-induced thrombocytopeniaNintedanibProgressive pulmonary fibrosis

Identifiers

PMID39342394
PMCPMC11439192

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.