Evidence map›Paper›PMID 39342392›Full record

ArticleBiological research2024

LYP regulates SLP76 and other adaptor proteins in T cells.

Virginia Ruiz-Martín, Tamara Marcos, José María de Pereda, Mariano Sánchez-Crespo, Miguel Angel de la Fuente, Yolanda Bayón, Andrés Alonso

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In one paragraph

Article in Biological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Virginia Ruiz-MartínUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain.
Tamara MarcosUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain.
José María de PeredaInstituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-Universidad de Salamanca, Campus Unamuno, 37007, Salamanca, Spain.
Mariano Sánchez-CrespoUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain.
Miguel Angel de la FuenteUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain.
Yolanda BayónUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain. ybayon@ibgm.uva.es.
Andrés AlonsoUnidad de Excelencia Instituto de Biología y Genética Molecular (IBGM), CSIC-Universidad de Valladolid, c/ Sanz y Forés 3, 47003, Valladolid, Spain. andres.alonso.garcia@uva.es.ORCID http://orcid.org/0000-0001-8674-9378

Funding

Agencia Estatal de Investigación MCIN/AEI/10.13039/501100011033Consejería de Sanidad, Junta de Castilla y León CCVC8485Junta de Castilla y León CLC-2017-01
6 · The paper itself

Abstract

backgroundThe LYP tyrosine phosphatase presents a SNP (1858C > T) that increases the risk of developing autoimmune diseases such as type I diabetes and arthritis. It remains unclear how this SNP affects LYP function and promotes the development of these diseases. The scarce information about LYP substrates is in part responsible for the poor understanding of LYP function.

resultsIn this study, we identify in T lymphocytes several adaptor proteins as potential substrates targeted by LYP, including FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2. We also show that LYP co-localizes with SLP76 in microclusters, upon TCR engagement.

conclusionsThese data indicate that LYP may modulate T cell activation by dephosphorylating several adaptor proteins, such as FYB, SLP-76, HS-1, Vav, SKAP1 and SKAP2 upon TCR engagement.

Indexed as

Adaptor Proteins, Signal TransducingPhosphoproteinsSignaling Lymphocytic Activation Molecule Associated ProteinT-LymphocytesHumansJurkat CellsLymphocyte ActivationPhosphorylationProtein Tyrosine PhosphatasesReceptors, Antigen, T-CellAdaptor Proteins, Signal TransducingPhosphoproteinsProtein Tyrosine PhosphatasesReceptors, Antigen, T-CellSH2D1A protein, humanSignaling Lymphocytic Activation Molecule Associated ProteinSLP-76 signal Transducing adaptor proteinsFYBLYP (lymphoid phosphatase)Protein tyrosine phosphatase (PTP)SKAP2SLP76T-cellT-cell receptor (TCR)

Identifiers

PMID39342392
PMCPMC11438317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.