ArticleArthritis research & therapy2024
Effects of chronic ankle instability after grade I ankle sprain on the post-traumatic osteoarthritis.
Article in Arthritis research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Contralateral Balance Training Improves Postural Control and Functional Recovery After Arthroscopic Anterior Talofibular Ligament Repair: A Prospective, Randomized, Single-Blind Trial.Sports medicine - open · 2026Article
- Effects of Vibro-Stimulation Ankle Bracing on Tactile Sensation and Center of Pressure Dynamics in Individuals with Chronic Ankle Instability: A Randomized Clinical Trial.Healthcare (Basel, Switzerland) · 2026Article
- Investigation of acute and chronic injury mechanisms of the deltoid ligament: insights from finite element analysis and animal study.Journal of orthopaedic surgery and research · 2026Article
- Current concepts in arthroscopic treatment for chronic lateral ankle instability: a clinical practice review.Annals of joint · 2026Review
- Electroacupuncture Combined with Diclofenac Emulgel for Post-Traumatic Ankle Osteoarthritis: A Randomized Controlled Trial Protocol.Journal of pain research · 2026Article
- Associations among ankle cartilage composition and ultrasound based measures of cartilage health in those with chronic ankle instability.Clinical rheumatology · 2025Article
- Osteoarthritis.Nature reviews. Disease primers · 2025Review
- Clinical impairments associated with ankle disability in patients with acute lateral ankle sprain.Frontiers in public health · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUntreated acute ankle sprains often result in chronic ankle instability (CAI) and can ultimately lead to the development of post-traumatic osteoarthritis (PTOA). At present, a typical animal model of ankle instability in mice is established by transecting the ligaments around the ankle joint. This study aimed to establish a grade I acute ankle sprain animal model by rapid stretching of peri-ankle joint ligaments. Furthermore, we tried to explore the pathophysiological mechanism of ankle osteoarthritis.
methodsIn all, 18 male C57BL/6 J mice (7 weeks) were randomly divided into three groups: calcaneofibular ligament (CFL) laxity group, deltoid ligament (DL) laxity group, and SHAM group. One week after the surgical procedure, all mice were trained to run in the mouse rotation fatigue machine daily. The mice were tested on the balance beam before surgery and three days, 4 weeks, 8 weeks, and 12 weeks after surgery. Footprint analyses were performed on each mouse before surgery and 12 weeks after surgery. Micro-CT scanning was then performed to evaluate the degeneration of ankle joints and histological staining was performed to analyze and evaluate PTOA caused by ankle joint instability.
resultsAfter surgery, the mice in the CFL and DL laxity groups took longer to cross the balance beam and slipped more often than those in the SHAM group (p < 0.05). The step length and width in the CFL and DL laxity groups were significantly shorter and smaller than those in the SHAM group 12 weeks after surgery (p < 0.05). There was a significant increase in the bone volume fraction (BV/TV) in the CFL and DL laxity groups compared with the SHAM group (p < 0.05). Histological staining results suggested obvious signs of PTOA in the CFL and DL laxity groups.
conclusionsBased on CFL and DL laxity in a mouse ankle instability model, this study suggests that grade I ankle sprain can contribute to chronic ankle instability, impair motor coordination and balance, and eventually lead to PTOA of ankle with significant degeneration of its adjacent joints.
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