Evidence map›Paper›PMID 39342233›Full record

ArticleBMC pediatrics2024

Serum salicylic acid levels in children with Kawasaki disease.

Hitoshi Honma, Sae Takahashi, Jun Sada, Hiroaki Somiya, Hiromitsu Mori, Taichiro Muto, Yoshinori Ito, Akihisa Okumura

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Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hitoshi HonmaDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan. honma.hitoshi.045@mail.aichi-med-u.ac.jp.
Sae TakahashiDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Jun SadaDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Hiroaki SomiyaDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Hiromitsu MoriDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Taichiro MutoDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Yoshinori ItoDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.
Akihisa OkumuraDepartment of Pediatrics, Aichi Medical University, 1-1 Yazako Karimata, Nagakute, 480-1195, Aichi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to clarify serum salicylic acid (SA) levels in patients with Kawasaki disease (KD) after the administration of moderate-dose acetylsalicylic acid (ASA) and their relationship with the therapeutic effect.

methodsWe retrospectively analyzed the clinical data of 142 children with KD. We measured serum SA trough levels during the acute and recovery periods and determined their relationship with clinical and laboratory parameters.

resultsThe median age of patients was 2.4 years. Thirty-one patients had incomplete KD, 29 were intravenous immunoglobulin (IVIG) non-responders, and one patient had coronary artery lesions. The median ASA dose was 49.7 mg/kg/day. The median serum SA level was 22 µg/mL in the acute period and 15 µg/mL in the recovery period, with 45 (33%) in the acute period and 60 (44%) in the recovery period below the limit of measurement (< 10 µg/mL). Serum SA levels during the recovery period were significantly lower in patients who received steroids. There were no significant differences in IVIG responsiveness based on serum SA levels.

conclusionsSerum SA trough levels in KD patients treated with moderate-dose ASA were highly variable and did not reach sufficient levels. Serum SA levels were not associated with IVIG responsiveness.

Indexed as

AspirinImmunoglobulins, IntravenousMucocutaneous Lymph Node SyndromeSalicylic AcidAnti-Inflammatory Agents, Non-SteroidalChildChild, PreschoolFemaleHumansInfantMaleRetrospective StudiesTreatment OutcomeAnti-Inflammatory Agents, Non-SteroidalAspirinImmunoglobulins, IntravenousSalicylic AcidAcetylsalicylic acidIntravenous immunoglobulinKawasaki diseaseSerum salicylic acid levelSteroid

Identifiers

PMID39342233
PMCPMC11438225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.