Evidence map›Paper›PMID 39342083›Full record

ArticleBMC microbiology2024

Peritoneal dialysis promotes microbial-driven biosynthesis pathways of sesquiterpenes and triterpenes compounds in end-stage renal disease patients.

Xinran Wang, Siqi Yao, Xinyu Yang, Yuxin Li, Zheng Yu, Jing Huang, Jianwen Wang

Abstract read
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In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinran Wang *Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Siqi Yao *Human Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China.
Xinyu YangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Yuxin LiDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China.
Zheng YuHuman Microbiome and Health Group, Department of Microbiology, School of Basic Medical Science, Central South University, Changsha, China.
Jing HuangDepartment of Parasitology, School of Basic Medical Science, Central South University, Changsha, China. jing_huang@csu.edu.cn.
Jianwen WangDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, China. jwwangdoc@163.com.

Funding

Hunan Province Traditional Chinese Medicine Research Program Project C2023045National Natural Science Foundation of China 32170071National Natural Science Foundation of China 32300051Natural Science Foundation of Hunan Province 2022JJ40663
6 · The paper itself

Abstract

The concept of the gut-kidney axis is gaining significant attention due to the close relationship between gut microbiota and kidney disease. Peritoneal dialysis is recognized as a crucial renal replacement therapy for end-stage renal disease (ESRD). The alterations in gut microbiota and related mechanisms after receiving this dialysis method are not fully understood. This study conducted shotgun metagenomic sequencing on fecal samples from 11 end-stage renal disease patients who did not receive dialysis (ESRD_N) and 7 patients who received peritoneal dialysis (ESRD_P). After quality control and correlation analysis of the data, our study is aimed at exploring the impact of peritoneal dialysis on the gut microbiota and health of ESRD patients. Our research findings indicate that the complexity and aggregation characteristics of gut microbiota interactions increase in ESRD_P. In addition, the gut microbiota drives the biosynthesis pathways of sesquiterpenes and triterpenes in ESRD_P patients, which may contribute to blood purification and improve circulation. Therefore, our research will lay the foundation for the prevention and treatment of ESRD.

Indexed as

FecesGastrointestinal MicrobiomeKidney Failure, ChronicPeritoneal DialysisSesquiterpenesTriterpenesAdultAgedBacteriaBiosynthetic PathwaysFemaleHumansMaleMetagenomicsMiddle AgedSesquiterpenesTriterpenesEnd-stage renal diseaseGut microbiotaMetagenome Shotgun sequencingPeritoneal dialysisSesquiterpenoid and triterpenoid biosynthesis

Identifiers

PMID39342083
PMCPMC11437912

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.