Observational studyJournal of perinatology : official journal of the California Perinatal Association2024
Blood volume collected for cultures in infants with suspected neonatal sepsis.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Umbilical Cord Quantitative Polymerase Chain Reaction and Sepsis Complications for Neonates.JAMA network open · 2026Article
- Revisiting time to blood culture positivity: can we decrease antibiotic exposure in the NICU?Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals.Infectious diseases and therapy · 2026Article
- Clinical features and risk factors of neonatal late-onset sepsis complicated by purulent meningitis.Frontiers in pediatrics · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate blood culture sample volumes, identify factors linked to insufficient samples, and compare volumes among neonates treated for culture-negative-sepsis, sepsis-rule-outs, and bloodstream infections (BSI).
methodsObservational cohort of blood cultures collected during NICU stay. Association of age, weight, gender, source, and collection time with lower-than-recommended volumes was determined by logistic regression. Blood culture inocula of patients with culture-negative-sepsis, sepsis rule-out, and BSI were compared using ANOVA.
results742 blood cultures were obtained from 292 neonates. Median inoculum was 1 mL (IQR:0.6-1.4), and 259 bottles (35%) had inocula <0.9 mL. Night shift sample collection was associated with lower-than-recommended volumes (p = 0.006). No difference in sample volumes was observed between culture-negative-sepsis, sepsis-rule-outs, and BSI (p = 0.5).
conclusionsMedian NICU blood culture volumes align with recommendations. Night shift collections correlate with lower volumes. Sample volumes don't differ in patients with culture-negative-sepsis, BSI, and sepsis-rule-out, and should not be a justification for longer duration of antibiotics.
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Registered trials
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