Evidence map›Paper›PMID 39341818›Full record

ArticleNPJ Parkinson's disease2024

Reduced subthalamic and subthalamic-cortical coherences associated with the therapeutic carryover effect of coordinated reset deep brain stimulation.

Lvpiao Zheng, Ziling Luo, Biswaranjan Mohanty, Sana Amoozegar, Luke A Johnson, Jerrold L Vitek, Jing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lvpiao ZhengDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-0478-7034
Ziling LuoDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Biswaranjan MohantyDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Sana AmoozegarDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.
Luke A JohnsonDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-9069-1436
Jerrold L VitekDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2308-6535
Jing WangDepartment of Neurology, University of Minnesota, Minneapolis, MN, USA. wang3444@umn.edu.

Funding

Deep Brain Stimulation in the Parkinsonian MonkeyR01NS037019 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek · 1999 to 2026
$14.5M
Understanding Circuit Dynamics in Parkinson's Disease using Real-Time Neural ControlP50NS123109 · NINDS · UNIVERSITY OF MINNESOTA · PI AMAN, JOSHUA E · 2021 to 2025
$11.3M
Neurophysiological Mechanisms Underlying Parkinsonian Motor SignsR01NS058945 · NINDS · UNIVERSITY OF MINNESOTA · PI LUKE Aaron JOHNSON, Jerrold L Vitek · 2008 to 2026
$9.6M
Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian MonkeyR37NS077657 · NINDS · UNIVERSITY OF MINNESOTA · PI VITEK, JERROLD L · 2018 to 2024
$4.4M
Optimizing coordinated reset deep brain stimulation for Parkinson's diseaseR01NS117822 · NINDS · UNIVERSITY OF MINNESOTA · PI WANG, JING · 2020 to 2024
$3.0M
Thalamic Coordinated Reset Deep Brain Stimulation for Upper Extremity Essential Tremor: Proof of Principle StudyUH3NS125162 · NINDS · UNIVERSITY OF MINNESOTA · PI Jerrold L Vitek, Jing Wang · 2023 to 2026
$2.7M
NINDS NIH HHS P50 NS123109NINDS NIH HHS R01 NS037019NINDS NIH HHS R01 NS058945NINDS NIH HHS R01 NS117822NINDS NIH HHS R37 NS077657NINDS NIH HHS UH3 NS125162U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS117822U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS117822, R01NS037019, R37NS077657, and P50NS123109
6 · The paper itself

Abstract

Coordinated reset deep brain stimulation (CR DBS), a promising treatment for Parkinson's disease (PD), is hypothesized to desynchronize neuronal populations. However, little in vivo data probes this hypothesis. In a parkinsonian nonhuman primate, we found that subthalamic CR DBS suppressed subthalamic and cortical-subthalamic coherences in the beta band, correlating with motor improvements. Our results support the desynchronizing mechanism of CR DBS and propose potential biomarkers for closed-loop CR DBS.

Identifiers

PMID39341818
PMCPMC11438994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.