Evidence map›Paper›PMID 39341817›Full record

ArticleTranslational psychiatry2024

Receptor and metabolic insights on the ability of caffeine to prevent alcohol-induced stimulation of mesolimbic dopamine transmission.

Valentina Bassareo, Riccardo Maccioni, Giuseppe Talani, Simone Zuffa, Yasin El Abiead, Irene Lorrai, Tomoya Kawamura, Sofia Pantis, Roberta Puliga, Romina Vargiu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Enhancing Neuroprotection Through Exercise: The Synergistic Effects of Bioactive Plant Compounds Via the CREB-BDNF Signaling Pathway.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Valentina Bassareo *Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.
Riccardo Maccioni *Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA. rmaccioni@scripps.edu.ORCID 0000-0003-1349-4903
Giuseppe Talani *Institute of Neuroscience - National Research Council (C.N.R.) of Italy, Cagliari, Italy.
Simone ZuffaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.ORCID 0000-0001-7237-3402
Yasin El AbieadSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Irene LorraiDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Tomoya KawamuraDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Sofia PantisDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.
Roberta PuligaDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.
Romina VargiuDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.
Daniele LeccaDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.
Paolo EnricoDepartment of Biomedical Sciences, University of Sassari, Sassari, Italy.
Alessandra PeanaDepartment of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
Laura DazziDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, CA, USA.
Pietro Paolo SannaDepartment of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0002-8307-2151
Enrico SannaInstitute of Neuroscience - National Research Council (C.N.R.) of Italy, Cagliari, Italy.
Elio AcquasDepartment of Life and Environmental Sciences, University of Cagliari, Cittadella Universitaria Monserrato, Monserrato, CA, Italy.

Funding

Neurpsychopharmacology-Multidisciplinary TrainingT32AA007456 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 1985 to 2026
$13.4M
Gene Network Perturbations in Alcohol Dependence - A Systems BiologyApproachR01AA021667 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2013 to 2026
$6.1M
Alcohol-Induced Neuroinflammation and AUD Therapeutic MechanismsR01AA028982 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI Vez REPUNTE-CANONIGO, PIETRO P SANNA · 2022 to 2026
$2.0M
Fondazione Banco di Sardegna (Bank of Sardinia Foundation) Project ID F74I19000970007 (2018)NIAAA NIH HHS R01 AA021667NIAAA NIH HHS R01 AA028982NIAAA NIH HHS T32 AA007456Regione Autonoma della Sardegna (Sardinia Region) RAS, CRP2_537-CUP F71J090006200002U.S. Department of Health & Human Services | National Institutes of Health (NIH) AA021667U.S. Department of Health & Human Services | National Institutes of Health (NIH) AA028982U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) T32AA007456
6 · The paper itself

Abstract

The consumption of alcohol and caffeine affects the lives of billions of individuals worldwide. Although recent evidence indicates that caffeine impairs the reinforcing properties of alcohol, a characterization of its effects on alcohol-stimulated mesolimbic dopamine (DA) function was lacking. Acting as the pro-drug of salsolinol, alcohol excites DA neurons in the posterior ventral tegmental area (pVTA) and increases DA release in the nucleus accumbens shell (AcbSh). Here we show that caffeine, via antagonistic activity on A

Indexed as

CaffeineDopamineDopaminergic NeuronsEthanolNucleus AccumbensVentral Tegmental AreaAdenosine A2 Receptor AntagonistsAnimalsIsoquinolinesMaleRatsReceptor, Adenosine A2ASynaptic TransmissionAdenosine A2 Receptor AntagonistsCaffeineDopamineEthanolIsoquinolinesReceptor, Adenosine A2Asalsolinol

Identifiers

PMID39341817
PMCPMC11438888

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.