Evidence map›Paper›PMID 39341120›Full record

ArticleDevelopmental cognitive neuroscience2024

Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.

Douglas C Dean, M Dylan Tisdall, Jessica L Wisnowski, Eric Feczko, Borjan Gagoski, Andrew L Alexander, Richard A E Edden, Wei Gao, Timothy J Hendrickson, Brittany R Howell and 84 more

Abstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cognitive neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
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  3. Review
  4. Observational
  5. Article
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  8. Annual Research Review: Early conduct problems - precursors, outcomes, and etiology.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Review
  9. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  10. Review
  11. Precision functional imaging in infants using multi-echo fMRI at 7T.bioRxiv : the preprint server for biology · 2025
    Article
  12. Review
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

94 authors.

Douglas C DeanDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI, USA; Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. Electronic address: deaniii@wisc.edu.
M Dylan TisdallDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jessica L WisnowskiDepartment of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Eric FeczkoDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Borjan GagoskiDepartment of Radiology, Harvard Medical School, Boston, MA, USA; Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA.
Andrew L AlexanderDepartment of Medical Physics, University of Wisconsin-Madison, Madison, WI, USA; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA; Department of Psychiatry, University of Wisconsin-Madison, Madison, WI, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Wei GaoBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Department of Biomedical Sciences and Imaging, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Timothy J HendricksonMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA.
Brittany R HowellFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA; Department of Human Development and Family Science, Virginia Tech, Blacksburg, VA, USA.
Hao HuangDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kathryn L HumphreysDepartment of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA.
Tracy RigginsDepartment of Psychology, University of Maryland, College Park, MD, USA.
Chad M SylvesterDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA; Department of Radiology, Washington University in St. Louis, St. Louis, MO, USA; Taylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, MO, USA.
Kimberly B WeldonMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Essa YacoubCenter for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA.
Banu AhtamFetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Natacha BeckMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Suchandrima BanerjeeGE HealthCare, Menlo Park, CA, USA.
Sergiy BorodayMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Arvind CaprihanThe Mind Research Network, Albuquerque, NM, USA.
Bryan CaronMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Samuel CarpenterDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Yulin ChangSiemens Medical Solutions USA Inc, PA, USA.
Ai Wern ChungFetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Matthew CieslakPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
William T ClarkeWellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Anders DaleDepartment of Radiology, University of California San Diego, La Jolla, CA, USA; Multimodal Imaging Laboratory, University of California San Diego, La Jolla, CA, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA.
Samir DasMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Christopher W Davies-JenkinsRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Alexander J DuffordDepartment of Psychiatry and Center for Mental Health Innovation, Oregon Health & Science University, Portland, OR, USA.
Alan C EvansMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Laetitia FesselierMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Sandeep K GanjiMR Clinical Science, Philips Healthcare, Best, the Netherlands.
Guillaume GilbertMR Clinical Science, Philips Healthcare, Mississauga, Ontario, Canada.
Alice M GrahamDepartment of Psychiatry, Oregon Health & Science University, Portland, OR, USA.
Aaron T GudmundsonRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Maren Macgregor-HannahMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Michael P HarmsDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
Tom HilbertAdvanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland,; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland,; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA; Department of Radiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
M Okan IrfanogluQuantitative Medical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
Steven KecskemetiWaisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Tobias KoberAdvanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland,; Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland,; LTS5, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Joshua M KupermanDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Bidhan LamichhaneCenter for Health Sciences, Oklahoma State University, Tulsa, OK, USA.
Bennett A LandmanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.
Xavier Lecour-BourcherMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Erik G LeeMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA.
Xu LiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Leigh MacIntyreMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; Lasso Informatics, Canada.
Cecile MadjarMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Mary Kate ManhardDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Andrew R MayerThe Mind Research Network, Albuquerque, NM, USA.
Kahini MehtaPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lucille A MooreMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Saipavitra Murali-ManoharRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Cristian NavarroCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.
Mary Beth NebelCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA; Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, MD, USA.
Sharlene D NewmanAlabama Life Research Institute, University of Alabama, Tuscaloosa, AL, USA; Department of Psychology, University of Alabama, Tuscaloosa, AL, USA.
Allen T NewtonDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Monroe Carell Jr. Children's Hospital at Vandebrilt, Vanderbilt University Medical Center, Nashville, TN, USA.
Ralph NoeskeGE HealthCare, Munich, Germany.
Elizabeth S NortonDepartment of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL, USA; Department of Medical Social Sciences, Feinberg School of Medicine, Chicago, IL, USA.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Regis Ongaro-CarcyMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Xiawei OuDepartment of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Minhui OuyangDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Todd B ParrishDepartment of Radiology, Feinberg School of Medicine, Chicago, IL, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
James J PekarRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Thomas PengoMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, USA.
Carlo PierpaoliQuantitative Medical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.
Russell A PoldrackDepartment of Psychology, Stanford University, Stanford, CA, USA.
Vidya RajagopalanDepartment of Pediatrics, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA; Department of Radiology, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, CA, USA.
Dan W RettmannGE HealthCare, Rochester, MN, USA.
Pierre RiouxMcGill Centre for Integrative Neuroscience, McGill University, Montréal, Québec, Canada; Montréal Neurological Institute-Hospital, Montréal, Québec, Canada; McConnell Brain Imaging Centre, McGill University, Montréal, Québec, Canada.
Jens T RosenbergAdvanced Magnetic Resonance Imaging and Spectroscopy Facility, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Taylor SaloPenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Theodore D SatterthwaitePenn Lifespan Informatics and Neuroimaging Center (PennLINC), Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lisa S ScottDepartment of Psychology, University of Florida, Gainesville, FL, USA.
Eunkyung ShinDepartment of Psychology, Pennsylvania State University, University Park, PA, USA.
Gizeaddis SimegnRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
W Kyle SimmonsDepartment of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA; OSU Biomedical Imaging Center, Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.
Yulu SongRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Barry J TikalskyMasonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Jean TkachDepartment of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Peter C M van ZijlRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Jennifer VannestDepartment of Communication Sciences and Disorders, University of Cincinnati, Cincinnati, OH, USA; Communication Sciences Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Maarten VersluisMR Clinical Science, Philips Healthcare, Best, the Netherlands.
Yansong ZhaoMR Clinical Science, Philips Healthcare, Cleveland, OH, USA.
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA.
Damien A FairDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA. Electronic address: faird@umn.edu.
Christopher D SmyserDepartment of Neurology, Washington University in St. Louis, St. Louis, MO, USA; Department of Pediatrics, Washington University in St. Louis, St. Louis, MO, USA; Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA. Electronic address: smyserc@wustl.edu.
Jed T ElisonDepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USA. Electronic address: jtelison@umn.edu.
HBCD MRI Working Group

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
The Healthy Brain and Child Development National Consortium Administrative CoreU24DA055325 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTINA CHAMBERS, CHARLES Alexander NELSON · 2021 to 2026
$40.8M
Healthy Brain and Child Development National Consortium Data Coordinating CenterU24DA055330 · NIDA · WASHINGTON UNIVERSITY · PI ANDERS M DALE, Damien A Fair · 2021 to 2026
$34.6M
5/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055344 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Weili Lin · 2021 to 2026
$13.9M
6/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) Consortium VanderbiltU01DA055347 · NIDA · VANDERBILT UNIVERSITY · PI Laurie E Cutting, Sarah Scheiderich Osmundson · 2021 to 2026
$12.7M
5/24 Healthy Brain and Child Development National ConsortiumU01DA055353 · NIDA · BOSTON CHILDREN'S HOSPITAL · PI Michelle A Bosquet Enlow, Patricia Ellen Grant · 2021 to 2026
$12.1M
4/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055342 · NIDA · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR, JENNIFER J. VANNEST · 2021 to 2026
$11.9M
1/6 HBCD Prenatal Experiences and Longitudinal Development (PRELUDE) ConsortiumU01DA055352 · NIDA · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI ASHLEY ACHESON, LORRAINE M MCKELVEY · 2021 to 2026
$11.9M
HEALthy Brain and Child Development Study at UAB and UAU01DA055322 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Rajesh K Kana, Cassandra R. Newsom · 2021 to 2026
$11.2M
23/24 Healthy Brain and Child Development National ConsortiumU01DA055367 · NIDA · WASHINGTON UNIVERSITY · PI RYAN H BOGDAN, CYNTHIA Elise ROGERS · 2021 to 2026
$10.8M
7/24 Healthy Brain and Child Development National ConsortiumU01DA055350 · NIDA · JOHNS HOPKINS UNIVERSITY · PI JAMES J. PEKAR, ANDREW J. SATIN · 2021 to 2026
$10.7M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
NCATS NIH HHS UL1 TR002369NIA NIH HHS K99 AG080084NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R01 EB032788NIBIB NIH HHS R21 EB031547NIBIB NIH HHS R21 EB033516NICHD NIH HHS P50 HD103537NIDA NIH HHS U01 DA055316NIDA NIH HHS U01 DA055322NIDA NIH HHS U01 DA055338NIDA NIH HHS U01 DA055342NIDA NIH HHS U01 DA055344NIDA NIH HHS U01 DA055347NIDA NIH HHS U01 DA055349NIDA NIH HHS U01 DA055350NIDA NIH HHS U01 DA055352NIDA NIH HHS U01 DA055353NIDA NIH HHS U01 DA055354NIDA NIH HHS U01 DA055355NIDA NIH HHS U01 DA055357NIDA NIH HHS U01 DA055358NIDA NIH HHS U01 DA055359NIDA NIH HHS U01 DA055360NIDA NIH HHS U01 DA055361NIDA NIH HHS U01 DA055362NIDA NIH HHS U01 DA055363NIDA NIH HHS U01 DA055365NIDA NIH HHS U01 DA055366NIDA NIH HHS U01 DA055367NIDA NIH HHS U01 DA055369NIDA NIH HHS U01 DA055370NIDA NIH HHS U01 DA055371NIDA NIH HHS U24 DA055325NIDA NIH HHS U24 DA055330NIMH NIH HHS R01 MH122389NIMH NIH HHS R01 MH134966
6 · The paper itself

Abstract

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.

Indexed as

BrainChild DevelopmentMagnetic Resonance ImagingChildChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMagnetic Resonance SpectroscopyMaleMulticenter Studies as TopicNeuroimagingProspective StudiesDevelopmentHBCDInfantMRIMRSProtocol

Identifiers

PMID39341120
PMCPMC11466640

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