Evidence map›Paper›PMID 39341002›Full record

ArticlePsychoneuroendocrinology2025

Maternal high BMI: Sex-dimorphic alterations in maternal and offspring stress indices.

Sameera Abuaish, Vanessa Babineau, Seonjoo Lee, Benjamin Tycko, Frances A Champagne, Elizabeth Werner, Catherine Monk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sameera AbuaishDepartment of Basic Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O.Box 84428, Riyadh 11671, Saudi Arabia. Electronic address: syabuaish@pnu.edu.sa.
Vanessa BabineauDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Seonjoo LeeDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA.
Benjamin TyckoHackensack-Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA.
Frances A ChampagneDepartment of Psychology, University of Texas at Austin, Austin, TX, USA.
Elizabeth WernerDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.
Catherine MonkDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA; Department of Psychiatry, Columbia University Medical Center, New York, NY, USA.

Funding

Prenatal stress: the epigenetic basis of maternal and perinatal effectsR01MH092580 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHAMPAGNE, FRANCES A., MONK, CATHERINE E · 2011 to 2015
$3.4M
NIMH NIH HHS R01 MH092580
6 · The paper itself

Abstract

Maternal body mass index (BMI) influences pregnancy and birth outcomes along with child metabolic and neurodevelopmental health and fetal sex may be a moderating factor in these effects. Alternations in autonomic nervous system (ANS) functioning, identified in heart rate (HR) measurements, could present early markers of these prenatal programming effects in both the mother and the developing fetus. This study examines the associations between pre-pregnancy BMI and maternal and fetal ANS functioning and infant postnatal behavioral outcomes stratified by fetal sex. Pregnant women (N=176) were recruited at gestational week (GW) T1: 12-22 and categorized into Normal (BMI< 25) or High BMI (BMI > 25). Women attended laboratory sessions at T2: GW 23-28, and T3: GW 34-36 to assess maternal and fetal HR and HR variability (HRV) at baseline and after a stressor at T3. Infant behavior was assessed at 4 months using the Infant Behavior Questionnaire-Revised. Women with high BMI bearing female fetuses had higher HR and lower HRV at both gestational time points. Later in the third trimester, female fetuses of high BMI women exhibited lower HRV when challenged with a stressor. At 4 months, female infants were rated as having lower scores on the Orienting/Regulatory scale. Our findings provide evidence of female sex-specific programming of maternal pre-pregnancy BMI on maternal ANS regulation and neurodevelopment identified in-utero and continuing into early infancy.

Indexed as

Autonomic Nervous SystemBody Mass IndexHeart RatePrenatal Exposure Delayed EffectsStress, PsychologicalAdultFemaleHumansInfantInfant BehaviorMaleMothersPregnancyPregnancy ComplicationsSex CharacteristicsSex FactorsFetal heart rateHeart rate variabilityHigh BMIInfant behaviorPregnancyPrenatal programming

Identifiers

PMID39341002
PMCPMC11568910

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.