Evidence map›Paper›PMID 39340927›Full record

ArticleBiochemical and biophysical research communications2024

Ocular tear fluid biomarkers collected by contact lenses.

Nikolay Boychev, Vincent Yeung, Menglu Yang, Levi N Kanu, Amy E Ross, Liangju Kuang, Lin Chen, Joseph B Ciolino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemical and biophysical research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nikolay BoychevSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA. Electronic address: nboychev@meei.harvard.edu.
Vincent YeungSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.
Menglu YangSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.
Levi N KanuSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.
Amy E RossSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.
Liangju KuangSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.
Lin ChenSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA; Department of Optometry and Visual Science, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.
Joseph B CiolinoSchepens Eye Research Institute, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.

Funding

VISION RESEARCHP30EY003790 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Patricia Ann D'Amore · 1985 to 2026
$25.5M
CORNEAL STROMAL-EPITHELIAL INTERACTIONS DURING REPAIRR01EY005665 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI Joseph B. Ciolino · 1985 to 2026
$14.4M
Antibiotic eluting contact lenses for the treatment of bacterial keratitisR01EY026640 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI CIOLINO, JOSEPH B. · 2017 to 2020
$2.0M
NEI NIH HHS P30 EY003790NEI NIH HHS R01 EY005665NEI NIH HHS R01 EY026640
6 · The paper itself

Abstract

purposeTo collect tear fluid biomarkers from contact lenses (CLs) and determine the impact of CL wear duration.

methodsRabbits were fitted with commercial etafilcon A CLs, which were collected after 1 min, 4 and 8 h (n = 4/time point). Tear fluid proteins and cytokines were extracted from the CLs and quantified. An exploratory comparison was performed between CLs and Schirmer Strips (SS) for a 1 min duration.

resultsThe concentration of MUC5AC was significantly higher after 4 h of CL wear. The expression of all investigated cytokines (IL-1α, IL-1β, IL-8, IL-17A, IL-21, Leptin, MIP-1β, MMP-9, NCAM-1, and TNF-α) was detectable after 1 min of CL wear, and over time, all showed significant variations throughout the 8-h CL wear period. Notably, IL-1α significantly increased by 8 h of CL wear, while MMP-9 decreased. Albumin and lysozyme did not show significant variations with CL wear. Differences between CLs and SS after 1 min were statistically significant for albumin, Leptin, TNF-α, IL-1α, IL-1β, and IL-8.

conclusionsThe duration of CL wear significantly affects the collection of some tear fluid biomarkers. Albumin, MUC5AC, and cytokines may have individual and synergistic diagnostic or prognostic potential. CLs and SS were similar for lysozyme and MUC5AC but differed in the collection of albumin and some cytokines. CLs are a viable tear fluid collection method for biomarker analyses and can be immediately added as a routine clinical test by being FDA-approved medical devices.

Indexed as

BiomarkersCytokinesTearsAnimalsContact LensesEye ProteinsMaleMethacrylatesMucin 5ACRabbitsBiomarkersCytokinesetafilconEye ProteinsMethacrylatesMucin 5ACtear proteinsBiomarkersContact lensesCytokinesOcular surfaceProteinsTear fluid

Identifiers

PMID39340927
PMCPMC11586051

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.