Evidence map›Paper›PMID 39340727›Full record

ArticleJapanese journal of ophthalmology2024

Outcomes of five cases of retinoblastoma with optic nerve invasion on imaging.

Tamae Onishi, Sachiko Nishina, Tadashi Yokoi, Tomoyo Yoshida, Shion Hayashi, Hazuki Morikawa-Anzai, Noriyuki Azuma, Chikako Kiyotani, Keita Terashima, Takako Yoshioka and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tamae OnishiDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Sachiko NishinaDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan. nishina@ncchd.go.jp.
Tadashi YokoiDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Tomoyo YoshidaDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Shion HayashiDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Hazuki Morikawa-AnzaiDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Noriyuki AzumaDivision of Ophthalmology, National Center for Child Health and Development, 2-10-1 Okura Setagaya-ku, Tokyo, Japan.
Chikako KiyotaniChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Keita TerashimaChildren's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Takako YoshiokaDepartment of Pathology, National Center for Child Health and Development, Tokyo, Japan.
Hideki OgiwaraDivision of Neurosurgery, National Center for Child Health and Development, Tokyo, Japan.
Hiroshi FujiDivision of Radiation Oncology, National Center for Child Health and Development, Tokyo, Japan.
Masayuki KitamuraDepartment of Diagnostic Radiology, National Center for Child Health and Development, Tokyo, Japan.
Yoshiyuki TsutsumiDepartment of Diagnostic Radiology, National Center for Child Health and Development, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the timing of enucleation, treatment course, and outcome for retinoblastoma (RB) with optic nerve (ON) invasion on imaging. STUDY

designRetrospective clinical study.

methodsOf the 160 patients with RB who presented to the National Center for Child Health and Development in Japan between 2005 and 2022, ON invasion on imaging at the initial presentation was seen in five patients. The clinical, computed tomography (CT), and magnetic resonance imaging (MRI) findings, and treatment courses were reviewed retrospectively.

resultsMRI showed ON invasion in all five patients (three with unilateral RB, 2 with bilateral RB); in two patients CT detected no invasion. Enucleation was performed in four patients, three of whom underwent neoadjuvant therapy and one had a positive ON resection margin following the enucleation as initial treatment. One patient did not undergo enucleation due to cerebrospinal fluid dissemination. All enucleated patients underwent adjuvant chemotherapy. Four patients underwent radiotherapy. During follow-up (mean, 89.4 months), four patients survived and one died.

conclusionMRI is recommended to evaluate ON invasion and determine the timing of enucleation for RB. The appropriate choice of neoadjuvant or adjuvant therapy would be helpful to avoid radiotherapy for RB with ON invasion on imaging.

Indexed as

Eye EnucleationMagnetic Resonance ImagingNeoplasm InvasivenessOptic NerveOptic Nerve NeoplasmsRetinal NeoplasmsRetinoblastomaTomography, X-Ray ComputedChild, PreschoolFemaleFollow-Up StudiesHumansInfantMaleRetrospective StudiesTreatment OutcomeEnucleationMagnetic resonance imagingNeoadjuvant chemotherapyOptic nerve invasionRetinoblastoma

Identifiers

PMID39340727
PMCPMC11607017

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.