Evidence map›Paper›PMID 39340625›Full record

ArticleBrain imaging and behavior2024

Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia.

Huiru Li, Yi Lu, Wei Xie, Junjie Ye, Qing Wang, Zhenguang Zhang, Yuanming Jiang, Zongfang Li

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Article in Brain imaging and behavior, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Huiru Li *Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yi Lu *Department of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Wei XieDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Junjie YeYunnan Population and Family Planning Institute, Kunming, Yunnan, China.
Qing WangDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zhenguang ZhangDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yuanming JiangDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Zongfang LiDepartment of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. Lizf_1111@163.com.

Funding

the Doctoral Research Fund of the First Affiliated Hospital of Kunming Medical University 2022BS017the Yunnan Provincial Education Department Scientific Research Fund Project 2024J0181Yunnan Fundamental Research Projects 202401AU070043
6 · The paper itself

Abstract

The etiology of classical trigeminal neuralgia (CTN) is still unclear. A better understanding of the cerebral structural and functional changes in female patients with CTN may provide important novel insights into the pathophysiologic mechanisms of female CTN. A total 37 female CTN patients were included and referred to MRI scans, comprising with 19 left CTN and 18 right CTN patients. We analyzed the volume and shape of subcortical gray matter (GM), and the functional connectivity (FC) between the accumbens nucleus (NAc) and whole brain in right and left CTN patients respectively. We found left CTN patients had a reduced right NAc volume compared to controls, similarly, the right CTN had the decreased volume in the left NAc. Vertex-wise shapes of right NAc in left CTN patients showed significant regional shape deformation on the anterior, medial and ventroposterior aspects, in contrast, left NAc of right CTN patients showed significant regional shape deformation on the anterior and posterior aspect. Furthermore, patients with left CTN showed significantly lower FC between the right NAc and right orbitofrontal cortex than control subjects. The volume of NAc in all CTN was significantly related to the perception of present pain intensity. The CTN might be majorly caused by volume reduction in NAc. A greater understanding of the neurobiological basis of pain-related changes in NAc will provide the knowledge for the development of novel NAc based therapeutic targets for pain management or even prevention in CTN patients.

Indexed as

Gray MatterMagnetic Resonance ImagingTrigeminal NeuralgiaAdultAgedBrainBrain MappingFemaleFunctional LateralityHumansMiddle AgedNeural PathwaysNucleus AccumbensOrgan SizeAccumbens nucleusBrain imagingClassical trigeminal neuralgiaPain

Identifiers

PMID39340625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.