Evidence map›Paper›PMID 39340619›Full record

ArticleBulletin of experimental biology and medicine2024

Relationship between HLA-II Gene Polymorphisms and Immune Response in COVID-19 Survivors and Volunteers Vaccinated against This Infection.

V I Dubrovina, D D Bryukhova, K M Korytov, A B Pyatidesyatnikova, V A Vishnyakov, S V Balakhonov

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

V I DubrovinaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru.
D D BryukhovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
K M KorytovIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
A B PyatidesyatnikovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
V A VishnyakovIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
S V BalakhonovIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The polymorphism of HLA class II genes was studied in COVID-19 survivors and vaccinated people. Six allelic variants of DQA1, 10 of DQB1, and 11 of DRB1 were identified. The DQA1*05:01 allele predominated in vaccinated volunteers and the DQA1*02:01, *01:03, and DQB1*06:02-8 alleles predominated in convalescents. In the groups with DQA1*01:01, *05:01 and *06:01 alleles, a high proportion of individuals seropositive for SARS-CoV-2 S protein was found. In the group with DQA1*02:01 allele, 40% of volunteers were found to have IgM and a significantly lower quantity of IgG to N protein of coronavirus. Comparative analysis showed a statistically significant increase in IL-10 levels in carriers of the DQA1*01:01 allele, which may indicate the influence of this allele on cytokine production. Further study of the immune response indices and their association with HLA class II gene polymorphism will provide better understanding of the mechanisms of COVID-19 immunogenesis.

Indexed as

COVID-19COVID-19 VaccinesHLA-DQ beta-ChainsPolymorphism, GeneticSARS-CoV-2AdultAllelesAntibodies, ViralFemaleHLA-DQ alpha-ChainsHLA-DRB1 ChainsHumansImmunoglobulin GImmunoglobulin MInterleukin-10MaleAntibodies, ViralCOVID-19 VaccinesHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DQB1 antigenHLA-DQ beta-ChainsHLA-DRB1 ChainsImmunoglobulin GImmunoglobulin MInterleukin-10Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-219; cytokine2; COVIDCoVII; SARSimmunity; HLA

Identifiers

PMID39340619

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.