Evidence map›Paper›PMID 39340347›Full record

ArticleClinical toxicology (Philadelphia, Pa.)2024

Detection of ethanol, cannabinoids, benzodiazepines, and opioids in older adults evaluated for serious injuries from falls.

Kavita M Babu, Yara K Haddad, Shakiera T Causey, Carmen C Vargas-Torres, Patricia Mae Martinez, Elizabeth M Goldberg, Jon D Dorfman, Julia A Bleser, Brittany P Chapman, Jeffrey T Lai and 8 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical toxicology (Philadelphia, Pa.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Kavita M BabuUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-2908-0468
Yara K HaddadDivision of Injury Prevention, National Center for Injury Prevention and Control, CDC, Atlanta, GA, USA.ORCID 0000-0001-6803-2410
Shakiera T CauseyNational Network of Public Health Institutes, New Orleans, LA, USA.ORCID 0000-0003-3104-8114
Carmen C Vargas-TorresIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9910-3354
Patricia Mae MartinezIcahn School of Medicine at Mount Sinai, New York, NY, USA.
Elizabeth M GoldbergUniversity of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0003-1817-0705
Jon D DorfmanUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Julia A BleserNational Network of Public Health Institutes, New Orleans, LA, USA.ORCID 0000-0002-7787-6225
Brittany P ChapmanUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0001-5761-5135
Jeffrey T LaiUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Riyadh SaifUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Romanda ElhoussanUniversity of Massachusetts Chan Medical School, Worcester, MA, USA.
Lindsey A GrahamDunlap and Associates, Inc., Stamford, CT, USA.
Alex J KrotulskiThe Center For Forensic Science Research & Education, Horsham, PA, USA.ORCID 0000-0003-1775-1882
Sara E WaltonThe Center For Forensic Science Research & Education, Horsham, PA, USA.
F Dennis ThomasDunlap and Associates, Inc., Stamford, CT, USA.
Barry K LoganThe Center For Forensic Science Research & Education, Horsham, PA, USA.ORCID 0000-0003-2400-4711
Roland C MerchantIcahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-7571-1294

Funding

GAPcare II: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency DepartmentK76AG059983 · NIA · UNIVERSITY OF COLORADO DENVER · PI GOLDBERG, ELIZABETH · 2019 to 2024
$1.5M
Intramural CDC HHS CC999999NIA NIH HHS K76 AG059983
6 · The paper itself

Abstract

backgroundIn 2020, there were 36.7 million reported falls among older adults (65+) in the United States. Ethanol and other sedating substances may increase fall risk among older adults due to their effect on cognitive and physical function. We estimate the prevalence of these substances in blood specimens of older adults presenting with a fall injury at selected trauma centers.

methodsThe initial study collected blood specimens from May 2020 through July 2021 from adults undergoing a trauma team evaluation at selected United States Level 1 trauma centers. We limited our study to older adults evaluated after a fall (

resultsAt least one substance was detected among 31.3% of samples analyzed. Prevalences of specific substances detected were 9.3% (95% CI: 6.0-12.6%) for benzodiazepines, 4.3% (95% CI: 2.0-6.7%) for cannabinoids, 8.0% (95% CI: 5.2-11.7%) for ethanol, and 15.0% (95% CI: 10.9-19.1%) for opioids. There were 18 deaths (6%; 95% CI: 3.6-9.3%). One-third of decedents had at least one substance detected in their blood. DISCUSSION: Opioids were the most frequently detected substance, followed by benzodiazepines, ethanol, and cannabinoids. Substance use prevalence was not uniform across demographics, with differences observed by sex and age.

conclusionsThis study provides insight into the frequency of the presence of substances that may contribute to fall risk and serious injury among older adults. Screening older adults for substances that impair cognitive and physical function can enhance clinical fall prevention efforts.

Indexed as

Accidental FallsAnalgesics, OpioidBenzodiazepinesCannabinoidsEthanolAgedAged, 80 and overFemaleHumansMalePrevalenceSubstance Abuse DetectionTrauma CentersUnited StatesWounds and InjuriesAnalgesics, OpioidBenzodiazepinesCannabinoidsEthanolEmergency medicineethanolfallsolder adultssubstances

Identifiers

PMID39340347
PMCPMC11725768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.