Evidence map›Paper›PMID 39340223›Full record

ArticleHead & neck2025

Tumor Microenvironment-Based Risk Stratification of Oropharyngeal Squamous Cell Carcinoma.

Alhadi Almangush, Lauri Jouhi, Caj Haglund, Jaana Hagström, Antti A Mäkitie, Ilmo Leivo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alhadi AlmangushDepartment of Pathology, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-4106-314X
Lauri JouhiDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0003-1354-8027
Caj HaglundResearch Programs Unit, Translational Cancer Medicine, University of Helsinki, Helsinki, Finland.
Jaana HagströmDepartment of Pathology, University of Helsinki, Helsinki, Finland.
Antti A MäkitieResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-0451-2404
Ilmo LeivoInstitute of Biomedicine, Pathology, University of Turku, Turku, Finland.

Funding

Finnish Cancer SocietyFinska LäkaresällskapetHelsinki University Hospital Research FundK. Albin Johansson FoundationMaritza and Reino Salonen FoundationSigrid Jusélius FoundationThe Finnish Dental Society ApolloniaTurku University Hospital Fund
6 · The paper itself

Abstract

backgroundEvaluation of the prognostic impact of tumor microenvironment (TME) has received attention in recent years. We introduce a TME-based risk stratification for oropharyngeal squamous cell carcinoma (OPSCC). MATERIAL AND

methodsA total of 182 patients treated for OPSCC at the Helsinki University Hospital were included. TME-based risk stratification was designed combining tumor-stroma ratio and stromal tumor-infiltrating lymphocytes assessed in hematoxylin and eosin-stained sections.

resultsIn multivariable analysis, TME-based risk stratification associated with poor disease-free survival with a hazard ratio (HR) of 2.68 (95% CI 1.11-6.48, p = 0.029). In addition, the proposed risk stratification was associated with poor disease-specific survival (HR 2.687, 95% CI 1.28-5.66, p = 0.009) and poor overall survival (HR 2.21, 95% CI 1.23-3.99, p = 0.008).

conclusionOur TME-based risk stratification provides a powerful prognostic tool that can be used in daily treatment planning of OPSCC together with tumor-related prognostic markers.

Indexed as

Carcinoma, Squamous CellOropharyngeal NeoplasmsTumor MicroenvironmentAdultAgedDisease-Free SurvivalFemaleFinlandHumansLymphocytes, Tumor-InfiltratingMaleMiddle AgedPrognosisRetrospective StudiesRisk Assessmentoropharyngeal squamous cell carcinomaprognosistumor‐infiltrating lymphocytestumor microenvironmenttumor‐stroma ratio

Identifiers

PMID39340223
PMCPMC11717971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.