Evidence map›Paper›PMID 39340014›Full record

ArticleVaccines2024

Impact of Oil-in-Water Adjuvanted β-Glucan on Innate Immune Memory in Piglets.

Razieh Ardali, Obdulio Garcia-Nicolas, Catherine Ollagnier, José María Sánchez Carvajal, Maria Levy, Pauline Yvernault, Francisco de Aboim Borges Fialho de Brito, Artur Summerfield

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Razieh ArdaliInstitute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.
Obdulio Garcia-NicolasInstitute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.ORCID 0000-0001-8922-5449
Catherine OllagnierSwine Research Unit, Agroscope, 1725 Posieux, Switzerland.ORCID 0000-0003-3725-7611
José María Sánchez CarvajalDepartment of Anatomy and Comparative Pathology and Toxicology, Faculty of Veterinary Medicine, University of Córdoba, 14014 Córdoba, Spain.ORCID 0000-0003-0852-3765
Maria LevySwine Research Unit, Agroscope, 1725 Posieux, Switzerland.
Pauline YvernaultSwine Research Unit, Agroscope, 1725 Posieux, Switzerland.
Francisco de Aboim Borges Fialho de BritoInstitute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.
Artur SummerfieldInstitute of Virology and Immunology, 3147 Mittelhäusern, Switzerland.

Funding

Federal Food Safety and Veterinary Office 1.20.01State Secretariat for Education and Research and Innovation of the Swiss Confederation under the umbrella of the European Union's Horizon Europe Project " European Partnership on Animal Health and Welfare 101136346
6 · The paper itself

Abstract

The non-specific protective effects offered by the concept of "innate immune memory" might represent a promising strategy to tackle early-life threatening infections. Here we tested the potential of an in vitro selected β-glucan in inducing trained immunity using an in vivo porcine model. We assessed the leukocyte transcriptome using blood transcriptomic module (BTM), proinflammatory cytokines, and clinical scoring after a first "training" and a second "stimulation" phase. The possible induction of innate immune memory was tested during a "stimulation" by an LPS-adjuvanted

Indexed as

adjuvantinnate immune memoryinnate tolerancepigletsβ-glucan

Identifiers

PMID39340014
PMCPMC11436110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.