Evidence map›Paper›PMID 39339982›Full record

ArticleViruses2024

Putting a Kink in HIV-1 Particle Infectivity: Rocaglamide Inhibits HIV-1 Replication by Altering Gag-Genomic RNA Interaction.

Paul Rosenfeld, Gatikrushna Singh, Amanda Paz Herrera, Juan Ji, Bradley Seufzer, Xiao Heng, Kathleen Boris-Lawrie, Alan Cochrane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Paul RosenfeldInstitute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.
Gatikrushna SinghDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0002-9870-5556
Amanda Paz HerreraDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
Juan JiDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA.
Bradley SeufzerDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.
Xiao HengDepartment of Biochemistry, University of Missouri, Columbia, MO 65211, USA.ORCID 0000-0001-8448-3596
Kathleen Boris-LawrieDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, MN 55108, USA.ORCID 0000-0001-6366-6270
Alan CochraneInstitute of Medical Sciences, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-8924-5682

Funding

Structural basis of the HIV-1 PBS-segment mediated RHA recruitment during assembly to bolster virus infectivityR01AI150460 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI HENG, XIAO · 2019 to 2021
$916k
Characterization of RHA:RT interactions in HIV-1 reverse transcriptionR21AI167742 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI BORIS-LAWRIE, KATHLEEN A., DICK, ROBERT A · 2022 to 2023
$458k
CIHR P-13024, PJT 178165NIAID NIH HHS R01 AI150460NIAID NIH HHS R21 AI167742
6 · The paper itself

Abstract

Our examination of RNA helicases for effects on HIV-1 protein production and particle assembly identified Rocaglamide (RocA), a known modulator of eIF4A1 function, as an inhibitor of HIV-1 replication in primary CD4

Indexed as

Benzofuransgag Gene Products, Human Immunodeficiency VirusHIV-1RNA, ViralVirus ReplicationCD4-Positive T-LymphocytesCell LineEukaryotic Initiation Factor-4AGenome, ViralHIV InfectionsHumansProtein BindingVirionVirus AssemblyBenzofuransEukaryotic Initiation Factor-4Agag Gene Products, Human Immunodeficiency VirusRNA, ViralrocaglamideeIF4A1guanosine-adenosine motifribonucleoprotein assemblyRNA structure

Identifiers

PMID39339982
PMCPMC11437399

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.