Evidence map›Paper›PMID 39339913›Full record

Observational studyViruses2024

Unveiling the Impact of Human Herpesviruses-Associated on CNS Infections: An Observational Study.

Caio Cesar L B Barrionuevo, Pedro P A Baptista, Ewerton F da Silva, Bernardo M da Silva, Cássia da L Goulart, Sabrina A de Melo, Valderjane A da Silva, Lara Laycia A de Souza, Rossicleia L Monte, Fernando F Almeida-Val and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Update on neurological complications of HIV.Current opinion in HIV and AIDS · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Caio Cesar L B BarrionuevoPrograma de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Pedro P A BaptistaFaculdade de Educação Física e Fisioterapia, Universidade Federal do Amazonas, Manaus 69060-001, Brazil.
Ewerton F da SilvaGerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
Bernardo M da SilvaPrograma de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Cássia da L GoulartPrograma de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Sabrina A de MeloGerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.
Valderjane A da SilvaPrograma de Pós-Graduação em Ciências da Saúde (PPGCIS), Manaus 69020-180, Brazil.
Lara Laycia A de SouzaPrograma de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.
Rossicleia L MonteGerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.ORCID 0000-0002-2881-8205
Fernando F Almeida-ValPrograma de Pós Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus 69055-038, Brazil.ORCID 0000-0001-9995-0249
Pablo Vinícius S FeitozaDepartamento de Clínica Cirúrgica, Faculdade de Medicina, Universidade Federal do Amazonas, Manaus 69020-170, Brazil.ORCID 0000-0003-2840-451X
Michele de S BastosGerência de Bacteriologia, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus 69040-000, Brazil.ORCID 0000-0003-3450-666X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human Herpesviruses (HHVs) play a significant role in neurological diseases such as encephalitis and meningitis, adding significant morbidity. This study aims to retrospectively analyze the effect of HHVs on patients with neurological symptoms, focusing on the

methodsThis retrospective cohort study included 895 patients suspected of viral CNS infections, utilizing molecular diagnosis via qPCR to identify HHVs in cerebrospinal fluid (CSF) samples. This was conducted at a reference tertiary care hospital for infectious diseases in the western Brazilian Amazon from January 2015 to December 2022, focusing on the

resultsThe findings revealed that 7.5% of the analyzed samples tested positive for HHVs, with Human

conclusionsThe results emphasize the need for comprehensive diagnostic approaches and tailored treatment strategies for CNS infections in immunocompromised individuals. The study calls for ongoing research and advancements in clinical practice to improve patient outcomes facing CNS infections, particularly those caused by HHVs.

Indexed as

HerpesviridaeHerpesviridae InfectionsAdolescentAdultAgedBrazilCentral Nervous System InfectionsCentral Nervous System Viral DiseasesChildChild, PreschoolCytomegalovirusFemaleHIV InfectionsHumansInfantMalecerebrospinal fluidCNS infectionsCSF analysisHIV/AIDSHuman Herpesviruses

Identifiers

PMID39339913
PMCPMC11437476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.