Evidence map›Paper›PMID 39339892›Full record

ArticleViruses2024

Characterization of Avian Influenza Viruses Detected in Kenyan Live Bird Markets and Wild Bird Habitats Reveal Genetically Diverse Subtypes and High Proportion of A(H9N2), 2018-2020.

Peninah Munyua, Eric Osoro, Joyce Jones, George Njogu, Genyan Yang, Elizabeth Hunsperger, Christine M Szablewski, Ruth Njoroge, Doris Marwanga, Harry Oyas and 12 more

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Peninah MunyuaDivision of Global Health Protection, US Centers for Disease Control and Prevention, Village Market, Nairobi P.O. Box 606-00621, Kenya.
Eric OsoroPaul G. Allen School for Global Health-Kenya, Washington State University, Nairobi P.O. Box 72938-00200, Kenya.
Joyce JonesNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
George NjoguDirectorate of Veterinary Services, Ministry of Agriculture and Livestock Development, P.O. Box 29114, Kangemi, Nairobi 00625, Kenya.
Genyan YangNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
Elizabeth HunspergerDivision of Global Health Protection, US Centers for Disease Control and Prevention, Village Market, Nairobi P.O. Box 606-00621, Kenya.
Christine M SzablewskiNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
Ruth NjorogePaul G. Allen School for Global Health-Kenya, Washington State University, Nairobi P.O. Box 72938-00200, Kenya.
Doris MarwangaPaul G. Allen School for Global Health-Kenya, Washington State University, Nairobi P.O. Box 72938-00200, Kenya.ORCID 0000-0002-9716-6052
Harry OyasDirectorate of Veterinary Services, Ministry of Agriculture and Livestock Development, P.O. Box 29114, Kangemi, Nairobi 00625, Kenya.
Ben AndagaluInfluenza Division, US Centers for Disease Control and Prevention, Village Market, Nairobi P.O. Box 606-00621, Kenya.ORCID 0000-0002-8678-7478
Romona NdanyiDirectorate of Veterinary Services, Ministry of Agriculture and Livestock Development, P.O. Box 29114, Kangemi, Nairobi 00625, Kenya.
Nancy OtienoCentre for Global Health Research, Kenya Medical Research Institute, Kisumu P.O. Box 1578-40100, Kenya.ORCID 0000-0002-7083-4735
Vincent ObandaDepartment of Veterinary Services, Kenya Wildlife Services, Nairobi P.O. Box 40241-00100, Kenya.ORCID 0000-0003-2587-5359
Carolyne NasimiyuPaul G. Allen School for Global Health-Kenya, Washington State University, Nairobi P.O. Box 72938-00200, Kenya.ORCID 0000-0002-7559-3109
Obadiah NjagiDirectorate of Veterinary Services, Ministry of Agriculture and Livestock Development, P.O. Box 29114, Kangemi, Nairobi 00625, Kenya.
Juliana DaSilvaNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
Yunho JangNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
John BarnesNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.
Gideon O EmukuleInfluenza Division, US Centers for Disease Control and Prevention, Village Market, Nairobi P.O. Box 606-00621, Kenya.
Clayton O OnyangoDivision of Global Health Protection, US Centers for Disease Control and Prevention, Village Market, Nairobi P.O. Box 606-00621, Kenya.
C Todd DavisNational Center for Immunization and Respiratory Diseases, US Centers for Disease Control and Prevention, 1600 Clifton Road, NE Atlanta, GA 30333, USA.

Funding

CGH CDC HHS U01 GH002143US Centers for Disease Control and Prevention CDC 1U01GH002143
6 · The paper itself

Abstract

Following the detection of highly pathogenic avian influenza (HPAI) virus in countries bordering Kenya to the west, we conducted surveillance among domestic and wild birds along the shores of Lake Victoria. In addition, between 2018 and 2020, we conducted surveillance among poultry and poultry workers in live bird markets and among wild migratory birds in various lakes that are resting sites during migration to assess introduction and circulation of avian influenza viruses in these populations. We tested 7464 specimens (oropharyngeal (OP) and cloacal specimens) from poultry and 6531 fresh fecal specimens from wild birds for influenza A viruses by real-time RT-PCR. Influenza was detected in 3.9% (n = 292) of specimens collected from poultry and 0.2% (n = 10) of fecal specimens from wild birds. On hemagglutinin subtyping, most of the influenza A positives from poultry (274/292, 93.8%) were H9. Of 34 H9 specimens randomly selected for further subtyping, all were H9N2. On phylogenetic analysis, these viruses were genetically similar to other H9 viruses detected in East Africa. Only two of the ten influenza A-positive specimens from the wild bird fecal specimens were successfully subtyped; sequencing analysis of one specimen collected in 2018 was identified as a low-pathogenicity avian influenza H5N2 virus of the Eurasian lineage, and the second specimen, collected in 2020, was subtyped as H11. A total of 18 OP and nasal specimens from poultry workers with acute respiratory illness (12%) were collected; none were positive for influenza A virus. We observed significant circulation of H9N2 influenza viruses in poultry in live bird markets in Kenya. During the same period, low-pathogenic H5N2 virus was detected in a fecal specimen collected in a site hosting a variety of migratory and resident birds. Although HPAI H5N8 was not detected in this survey, these results highlight the potential for the introduction and establishment of highly pathogenic avian influenza viruses in poultry populations and the associated risk of spillover to human populations.

Indexed as

Animals, WildBirdsFecesInfluenza A Virus, H9N2 SubtypeInfluenza in BirdsPhylogenyPoultryAnimalsEcosystemGenetic VariationHumansKenyaAfricaavian influenzalow pathogenicpoultry diseasessurveillance

Identifiers

PMID39339892
PMCPMC11436075

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.