Evidence map›Paper›PMID 39339889›Full record

ArticleViruses2024

Translation of Overlapping Open Reading Frames Promoted by Type 2 IRESs in Avian Calicivirus Genomes.

Yani Arhab, Tatyana V Pestova, Christopher U T Hellen

Abstract read
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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  5. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yani ArhabDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0002-6165-3203
Tatyana V PestovaDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0003-3543-256X
Christopher U T HellenDepartment of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY 11203, USA.ORCID 0000-0002-3982-2090

Funding

Mechanisms of eukaryotic translation and ribosome-associated mRNA surveillance and protein quality controlR35GM122602 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI TATYANA V PESTOVA · 2017 to 2026
$4.8M
Alternative mechanisms of different stages in eukaryotic translationR01GM097014 · NIGMS · SUNY DOWNSTATE MEDICAL CENTER · PI HELLEN, CHRISTOPHER ULRICH TRISTRAM · 2012 to 2022
$2.6M
NIGMS NIH HHS R01 GM097014NIGMS NIH HHS R35 GM122602NIH (NIGMS) 5 R01 GM097014NIH (NIGMS) 5 R35 GM122602
6 · The paper itself

Abstract

Caliciviruses have positive-sense RNA genomes, typically with short 5'-untranslated regions (5'UTRs) that precede the long open reading frame 1 (ORF1). Exceptionally, some avian caliciviruses have long 5'UTRs containing a picornavirus-like internal ribosomal entry site (IRES), which was likely acquired by horizontal gene transfer. Here, we identified numerous additional avian calicivirus genomes with IRESs, predominantly type 2, and determined that many of these genomes contain a ~200-300 codon-long ORF (designated ORF1*) that overlaps the 5'-terminal region of ORF1. The activity of representative type 2 IRESs from grey teal calicivirus (GTCV) and

Indexed as

CaliciviridaeGenome, ViralInternal Ribosome Entry SitesOpen Reading FramesProtein Biosynthesis5' Untranslated RegionsAnimalsRibosomesRNA, Viral5' Untranslated RegionsInternal Ribosome Entry SitesRNA, ViralcalicivirusEbp1IRESoverlapping reading frametranslation initiation

Identifiers

PMID39339889
PMCPMC11436067

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.