Evidence map›Paper›PMID 39339827›Full record

ArticleViruses2024

Honeysuckle-Derived miR2911 Inhibits Replication of Porcine Reproductive and Respiratory Syndrome Virus by Targeting Viral Gene Regions.

Xinyan Cao, Jiaxi Xue, Adnan Ali, Manyi Zhang, Jinliang Sheng, Yanming Sun, Yanbing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyan CaoCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Jiaxi XueCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Adnan AliCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Manyi ZhangXinjiang Production & Construction Corps Key Laboratory of Animal Biomedicine, Tumushuke 843900, China.
Jinliang ShengCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.
Yanming SunCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0000-0002-3979-2039
Yanbing ZhangCollege of Animal Science and Technology, Shihezi University, Shihezi 832003, China.ORCID 0009-0003-9564-3999

Funding

Xinjiang Corps Guiding Science and Technology Plan Project 2023ZD042Xinjiang Production & Construction Corps Key Laboratory of Animal biomedicine FMOF2023002
6 · The paper itself

Abstract

The highly abundant and stable antiviral small RNA derived from honeysuckle, known as miR2911, has been shown to play a key role in inhibiting influenza virus infection and SARS-CoV-2 infection. However, whether miR2911 inhibits the replication of porcine reproductive and respiratory syndrome virus (PRRSV) remains unknown. Hence, this study investigated the mechanisms underlying the action of miR2911 during PRRSV infection. Six targets of miR2911 within the PRRSV orf1 (Nsp2: 2459 to 2477, 1871 to 1892, 954 to 977, and 1271 to 1292; Nsp1: 274 to 296 and 822 to 841) were successfully identified by using the miRanda v1.0b software. The miR2911 target sequence was analyzed by target sequence comparison, and only individual base mutations existed in different prevalent strains, and the miR2911 target region was highly conserved among different strains. Subsequently, through the dual luciferase reporter gene assay and miR2911 overexpression assay, it was demonstrated that miR2911 significantly inhibits the replication of PRRSV by targeting regions of PRRSV Nsp1 and Nsp2. These findings offer new insights for the development of novel anti-PRRSV drugs.

Indexed as

LoniceraMicroRNAsPorcine respiratory and reproductive syndrome virusVirus ReplicationAnimalsCell LineGenes, ViralOpen Reading FramesPorcine Reproductive and Respiratory SyndromeRNA, ViralSwineViral Nonstructural ProteinsMicroRNAsRNA, ViralViral Nonstructural ProteinsantiviralhoneysucklemiR2911miRandatarget regionviral gene

Identifiers

PMID39339827
PMCPMC11435848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.