Evidence map›Paper›PMID 39339760›Full record

ArticleNutrients2024

Licorice Extract Isoliquiritigenin Protects Endothelial Function in Type 2 Diabetic Mice.

Lin Wang, Ruiwen Zhu, Chufeng He, Huixian Li, Qile Zhang, Yiu Ming Cheung, Fung Ping Leung, Wing Tak Wong

Abstract read
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lin WangSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Ruiwen ZhuSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Chufeng HeSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Huixian LiSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Qile ZhangSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.ORCID 0009-0006-9548-2314
Yiu Ming CheungSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Fung Ping LeungSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Wing Tak WongSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Funding

National Natural Science Foundation of China 81970423Research Grants Council of the Hong Kong 14101119Research Grants Council of the Hong Kong 14105022Research Grants Council of the Hong Kong 24163117
6 · The paper itself

Abstract

Endothelial dysfunction occurs prior to atherosclerosis, which is an independent predictor of cardiovascular diseases (CVDs). Diabetes mellitus impairs endothelial function by triggering oxidative stress and inflammation in vascular tissues. Isoliquiritigenin (ISL), one of the major bioactive ingredients extracted from licorice, has been reported to inhibit inflammation and oxidative stress. However, the therapeutic effects of ISL on ameliorating type 2 diabetes (T2D)-associated endothelial dysfunction remain unknown. In our animal study,

Indexed as

ChalconesDiabetes Mellitus, Type 2Endothelial CellsEndothelium, VascularGlycyrrhizaOxidative StressPlant ExtractsAnimalsAortaDiabetes Mellitus, ExperimentalInterleukin-1betaMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesChalconesGlycyrrhiza glabra extractInterleukin-1betaisoliquiritigeninPlant ExtractsReactive Oxygen Speciesendothelial dysfunctioninflammatory factorsinterleukin-1βisoliquiritigeninreactive oxygen speciestype 2 diabetes

Identifiers

PMID39339760
PMCPMC11435099

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.