Evidence map›Paper›PMID 39339673›Full record

ReviewNutrients2024

Lactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus.

Merve Kaplan, Merve Baktıroğlu, Arda Erkan Kalkan, Ahmet Alperen Canbolat, Mauro Lombardo, António Raposo, José Luiz de Brito Alves, Anna Maria Witkowska, Sercan Karav

Abstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Lactoferrin: Properties and Potential Uses in the Food Industry.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Merve KaplanTheoretical and Physical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 2JD, UK.
Merve BaktıroğluDepartment of Gynecological Oncology, Istanbul University, Istanbul 34452, Turkey.
Arda Erkan KalkanDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey.ORCID 0009-0003-6141-862X
Ahmet Alperen CanbolatDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey.ORCID 0009-0001-7149-922X
Mauro LombardoDepartment for the Promotion of Human Science and Quality of Life, San Raffaele Open University, Via di 11 Val Cannuta 247, 00166 Rome, Italy.ORCID 0000-0001-7509-5487
António RaposoCBIOS (Research Center for Biosciences and Health Technologies), Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal.ORCID 0000-0002-5286-2249
José Luiz de Brito AlvesDepartment of Nutrition, Health Science Center, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0003-4696-3809
Anna Maria WitkowskaDepartment of Food Biotechnology, Bialystok Medical University, 15-089 Bialystok, Poland.ORCID 0000-0002-0092-3409
Sercan KaravDepartment of Molecular Biology and Genetics, Canakkale Onsekiz Mart University, Canakkale 17100, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactoferrin is a multifunctional glycoprotein naturally found in mammalian secretions, predominantly in colostrum and milk. As a key component of dairy foods, lactoferrin enhances viral protection and boosts human health, owing to its fundamental properties including antiviral, anti-inflammatory, and immune-modulatory effects. Importantly, the antiviral effect of lactoferrin has been shown against a range of viruses causing serious infections and threatening human health. One of the viruses that lactoferrin exerts significant antiviral effects on is the human papillomavirus (HPV), which is the most prevalent transmitted infection affecting a myriad of people around the world. Lactoferrin has a high potential to inhibit HPV via different mechanisms, including direct binding to viral envelope proteins or their cell receptors, thereby hindering viral entry and immune stimulation by triggering the release of some immune-related molecules through the body, such as lymphocytes. Along with HPV, lactoferrin also can inhibit a range of viruses including coronaviruses and hepatitis viruses in the same manner. Here, we overview the current knowledge of lactoferrin and its effects on HPV and other viral infections.

Indexed as

Antiviral AgentsLactoferrinPapillomavirus InfectionsAnimalsHuman Papillomavirus VirusesHumansPapillomaviridaeVirus InternalizationAntiviral AgentsLactoferrinantiviraldairy foodsHPVhuman papillomaviruslactoferrinmilknatural compound

Identifiers

PMID39339673
PMCPMC11435110

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.