Evidence map›Paper›PMID 39339663›Full record

ArticleNutrients2024

Iron Deficiency and Restless Sleep/Wake Behaviors in Neurodevelopmental Disorders and Mental Health Conditions.

Osman S Ipsiroglu, Parveer K Pandher, Olivia Hill, Scout McWilliams, Melissa Braschel, Katherine Edwards, Robin Friedlander, Elizabeth Keys, Calvin Kuo, Marion Suzanne Lewis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Osman S IpsirogluH-Behaviours Research Lab, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Parveer K PandherH-Behaviours Research Lab, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Olivia HillH-Behaviours Research Lab, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Scout McWilliamsH-Behaviours Research Lab, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.ORCID 0000-0003-1141-2775
Melissa BraschelClinical Research Support Unit, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.
Katherine EdwardsDivision of Child and Adolescent Psychiatry, BC Children's Hospital, Department of Psychiatry, University of British Columbia, Vancouver, BC V6H 3N1, Canada.
Robin FriedlanderDivision of Child and Adolescent Psychiatry, BC Children's Hospital, Department of Psychiatry, University of British Columbia, Vancouver, BC V6H 3N1, Canada.
Elizabeth KeysSchool of Nursing, University of British Columbia (Okanagan), Kelowna, BC V1V 1V7, Canada.ORCID 0000-0002-0251-0720
Calvin KuoSchool of Biomedical Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0001-8401-9136
Marion Suzanne LewisDepartment of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0002-6300-5381
Anamaria RichardsonGranville Pediatrics, 205-5678 Granville Street, Vancouver, BC V6M 1X7, Canada.
Alexandra L WagnerDepartment of Pediatrics, Division of Neurology, Charité University Hospital Berlin, 10117 Berlin, Germany.
David WensleyDivision of Respirology, BC Children's Hospital, Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3N1, Canada.ORCID 0000-0001-7228-4274

Funding

BC Children's Hospital Research Foundation N/A
6 · The paper itself

Abstract

Iron deficiency (ID) and restlessness are associated with sleep/wake-disorders (e.g., restless legs syndrome (RLS)) and neurodevelopmental disorders (attention deficit/hyperactivity and autism spectrum disorders (ADHD; ASD)). However, a standardized approach to assessing ID and restlessness is missing. We reviewed iron status and family sleep/ID history data collected at a sleep/wake behavior clinic under a quality improvement/quality assurance project. Restlessness was explored through patient and parental narratives and a 'suggested clinical immobilization test'. Of 199 patients, 94% had ID, with 43% having a family history of ID. ADHD (46%) and ASD (45%) were common conditions, along with chronic insomnia (61%), sleep-disordered breathing (50%), and parasomnias (22%). In unadjusted analysis, a family history of ID increased the odds (95% CI) of familial RLS (OR: 5.98,

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderNeurodevelopmental DisordersRestless Legs SyndromeAdolescentAnemia, Iron-DeficiencyChildChild, PreschoolFemaleHumansIron DeficienciesMaleMental HealthSleep Initiation and Maintenance Disordersattention deficit/hyperactivity disorderautism spectrum disordercircadian rhythm sleep disordersfetal alcohol spectrum disorderhematologic indicesinsomniairon deficiencyprenatal alcohol exposurerestless leg syndromerestless sleep disordersleep-disordered breathing

Identifiers

PMID39339663
PMCPMC11435348

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.