Evidence map›Paper›PMID 39339502›Full record

ArticleMolecules (Basel, Switzerland)2024

Development of a Simple and Validated LC-MS/MS Method for Quantitative Determination of Ketotifen in Beagle Dog Plasma and Its Application to Bioequivalence Study of Ketotifen Syrup Dosage Form.

Eunseo Song, Wang-Seob Shim, Doowon Choi, Yuna Song, Hyeong Geun Jo, Soobok Lee, Suk Han Jung, Yeo Jin Choi, Kyung-Tae Lee

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eunseo SongDepartment of Biomedical and Pharmaceutical Science, Graduated School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0009-0000-5927-7168
Wang-Seob ShimKyung Hee Drug Analysis Center, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0903-1386
Doowon ChoiDepartment of Biomedical and Pharmaceutical Science, Graduated School, Kyung Hee University, Seoul 02447, Republic of Korea.
Yuna SongDepartment of Biomedical and Pharmaceutical Science, Graduated School, Kyung Hee University, Seoul 02447, Republic of Korea.
Hyeong Geun JoDaewon Pharm. Co., Ltd., 386 Cheonhodae-ro, Gwangjin-gu, Seoul 04808, Republic of Korea.
Soobok LeeDaewon Pharm. Co., Ltd., 386 Cheonhodae-ro, Gwangjin-gu, Seoul 04808, Republic of Korea.
Suk Han JungDaewon Pharm. Co., Ltd., 386 Cheonhodae-ro, Gwangjin-gu, Seoul 04808, Republic of Korea.
Yeo Jin ChoiDepartment of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-0635-4374
Kyung-Tae LeeDepartment of Biomedical and Pharmaceutical Science, Graduated School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-3141-3727

Funding

Daewon Pharmaceutical Co., Ltd., Republic of Korea DW-5223
6 · The paper itself

Abstract

A highly accurate, precise, and simple liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for ketotifen (KTF) estimation from Beagle dog plasma was developed and validated, with ketotifen-d3 (KTF-d3) as the internal standard (IS). KTF and IS were detected on an API 4000 mass spectrometer in multiple reaction monitoring (MRM) mode in electrospray ionization (ESI) positive ionization mode. The transitions were monitored at

Indexed as

KetotifenTandem Mass SpectrometryTherapeutic EquivalencyAdministration, OralAnimalsChromatography, High Pressure LiquidChromatography, LiquidDogsLiquid Chromatography-Mass SpectrometryMaleReproducibility of ResultsKetotifenBeagle dog plasmabioanalytical method validationbioequivalenceketotifenLC–MS/MSsyrup

Identifiers

PMID39339502
PMCPMC11433888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.