Evidence map›Paper›PMID 39339403›Full record

ArticleMolecules (Basel, Switzerland)2024

Assessment of the Lipophilicity of Indole Derivatives of Betulin and Their Toxicity in a Zebrafish Model.

Zuzanna Rzepka, Katarzyna Bober-Majnusz, Justyna Magdalena Hermanowicz, Ewa Bębenek, Elwira Chrobak, Arkadiusz Surażyński, Dorota Wrześniok

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zuzanna RzepkaDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellońska, 41-200 Sosnowiec, Poland.ORCID 0000-0001-7892-0462
Katarzyna Bober-MajnuszDepartment of Analytical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland.ORCID 0000-0001-5150-0396
Justyna Magdalena HermanowiczDepartment of Pharmacodynamics, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland.ORCID 0000-0002-3985-4244
Ewa BębenekDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellońska, 41-200 Sosnowiec, Poland.ORCID 0000-0001-5592-4161
Elwira ChrobakDepartment of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellońska, 41-200 Sosnowiec, Poland.ORCID 0000-0001-9038-3444
Arkadiusz SurażyńskiDepartment of Medicinal Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.ORCID 0000-0003-4475-873X
Dorota WrześniokDepartment of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 4 Jagiellońska, 41-200 Sosnowiec, Poland.ORCID 0000-0002-6918-3330

Funding

Medical University of Bialystok, Poland B.SUB.24.334/01.SMedical University of Silesia in Katowice BNW-1-037/N/4/F, BNW-2-038/K/4/F
6 · The paper itself

Abstract

There are scientific studies indicating that the attachment of an indole moiety to the triterpene scaffold can lead to increased anticancer potential. Lipophilicity is one of the factors that may influence biological properties and is therefore an important parameter to determine for newly obtained compounds as drug candidates. In the present study, previously synthesized 3 and/or 28-indole-betulin derivatives were evaluated for lipophilicity by reversed-phase thin-layer chromatography. The experimental values of lipophilicity (logP

Indexed as

IndolesTriterpenesZebrafishAnimalsAntineoplastic AgentsBetulinic AcidEmbryo, NonmammalianHydrophobic and Hydrophilic InteractionsLarvaMolecular StructureAntineoplastic AgentsbetulinBetulinic AcidIndolesTriterpenesindolelipophilicityRP-TLCtriterpenoidszebrafish

Identifiers

PMID39339403
PMCPMC11434430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.