Evidence map›Paper›PMID 39339330›Full record

ReviewMolecules (Basel, Switzerland)2024

Research Progress of Fluorescent Probes for Detection of Glutathione (GSH): Fluorophore, Photophysical Properties, Biological Applications.

Yao Wang, Yanfei Li, Jinbo Cao, Xiyan Yang, Jiaxiang Huang, Mingyue Huang, Shaobin Gu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yao WangHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Yanfei LiHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Jinbo CaoHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Xiyan YangHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Jiaxiang HuangHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Mingyue HuangHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
Shaobin GuHenan International Joint Laboratory of Food Green Processing and Quality Safety Control, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.

Funding

the Key R&D Projects in Henan Province No. 221111111400the Key R&D Projects in Henan Province No. 241111314200the Major Science and Technology Special Projects in Henan Province No. 231100310200the Training Plan for Young Backbone Teachers in Higher Education Institutions of Henan Province No. 2023GGJS046
6 · The paper itself

Abstract

Intracellular biothiols, including cysteine (Cys), glutathione (GSH), and homocysteine (Hcy), play a critical role in many physiological and pathological processes. Among them, GSH is the most abundant non-protein mercaptan (1-10 mM) in cells, and the change in GSH concentration level is closely related to the occurrence of many diseases, such as Parkinson's disease, Alzheimer's disease, and neurological diseases. Fluorescent probes have attracted much attention due to their advantages of high specificity, high sensitivity, high selectivity, low cost, and high quantum yield. Methods that use optical probes for selective detection of GSH in vitro and in vivo are in high demand. In this paper, we reviewed the most recent five years of research on fluorescence probes for the detection of GSH, including the specific detection of GSH, dual-channel identification of GSH and other substances, and the detection of GSH and other biothiols. According to the type of fluorophore, we classified GSH fluorescent probes into eight classes, including BODIPY, 1,8-Naphthalimide, coumarin, xanthene, rhodamine, cyanine, benzothiazoles, and others. In addition, we roundly discuss the synthesis, detection mechanism, photophysical properties, and biological applications of fluorescent probes. We hope that this review will inspire the exploration of new fluorescent probes for GSH and other related analyses.

Indexed as

Fluorescent DyesGlutathioneAnimalsCoumarinsHumansCoumarinsFluorescent DyesGlutathionefluorescent probefluorophoreglutathioneliving cell imaging

Identifiers

PMID39339330
PMCPMC11434280

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.