Evidence map›Paper›PMID 39339303›Full record

ReviewMolecules (Basel, Switzerland)2024

Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity.

Jelena Dinić, Ana Podolski-Renić, Miroslav Novaković, Liang Li, Igor Opsenica, Milica Pešić

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jelena DinićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0003-3371-2381
Ana Podolski-RenićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0001-7412-3685
Miroslav NovakovićInstitute of Chemistry, Technology and Metallurgy-National Institute of the Republic of Serbia, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia.ORCID 0000-0002-4984-041X
Liang LiKey Laboratory of Bioactive Substance and Function of Natural Medicines, State Key Laboratory of Respiratory Health and Multimorbidity, NHC Key Laboratory of Biotechnology for Microbial Drugs, Department of Oncology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Tiantan Xili, Beijing 100050, China.ORCID 0000-0003-1893-1965
Igor OpsenicaFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11158 Belgrade, Serbia.ORCID 0000-0003-4942-4042
Milica PešićInstitute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Despota Stefana 142, 11108 Belgrade, Serbia.ORCID 0000-0002-9045-8239

Funding

"Belt and Road Innovative" Talents Exchange Foreign Experts Project DL2022194002LMinistry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-47/2024-03/200168Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-66/2024-03/200007Ministry of Science, Technological Development and Innovation of the Republic of Serbia 451-03-66/2024-03/200026
6 · The paper itself

Abstract

Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in addressing multidrug resistance in cancer therapy. Additionally, we discuss the modulation of P-gp activity by 55 natural product drugs, including derivatives for some of them, based on our team's research findings since 2011. Specifically, we prospect into sesquiterpenoids from the genera

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Biological ProductsAntineoplastic Agents, PhytogenicDrug Resistance, MultipleDrug Resistance, NeoplasmHumansNeoplasmsPlant ExtractsSerbiaAntineoplastic Agents, PhytogenicATP Binding Cassette Transporter, Subfamily B, Member 1Biological ProductsPlant Extractscancermultidrug resistancenatural product derivativesnatural productsP-glycoprotein

Identifiers

PMID39339303
PMCPMC11433820

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.