Evidence map›Paper›PMID 39339284›Full record

ArticleMolecules (Basel, Switzerland)2024

Fabrication of PLA-Based Nanoneedle Patches Loaded with Transcutol-Modified Chitosan Nanoparticles for the Transdermal Delivery of Levofloxacin.

Christina Samiotaki, Ioanna Koumentakou, Evi Christodoulou, Nikolaos D Bikiaris, Marilena Vlachou, Evangelos Karavas, Konstantina Tourlouki, Nikolaos Kehagias, Panagiotis Barmpalexis

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina SamiotakiLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0001-8931-2761
Ioanna KoumentakouLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0009-0002-6467-615X
Evi ChristodoulouLaboratory of Polymer Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-2730-0778
Nikolaos D BikiarisLaboratory of Pharmaceutical Technology, Division of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-0751-2802
Marilena VlachouSection of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimioupoli-Zografou, 15784 Athens, Greece.ORCID 0000-0002-2927-705X
Evangelos KaravasPharmathen S.A., Pharmaceutical Industry, Dervenakion Str. 6, Pallini Attikis, 15351 Athens, Greece.
Konstantina TourloukiNanotypos, Stivos, 57020 Thessaloniki, Greece.
Nikolaos KehagiasInstitute of Nanoscience and Nanotechnology, NCSR Demokritos, 15341 Paraskevi, Greece.ORCID 0000-0002-2698-383X
Panagiotis BarmpalexisLaboratory of Pharmaceutical Technology, Division of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-6765-512X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current transdermal drug delivery technologies, like patches and ointments, effectively deliver low molecular weight drugs through the skin. However, delivering larger, hydrophilic drugs and macromolecules remains a challenge. In the present study, we developed novel transdermal nanoneedle patches containing levofloxacin-loaded modified chitosan nanoparticles. Chitosan was chemically modified with transcutol in three ratios (1/1, 1/2, 1/3,

Indexed as

Administration, CutaneousChitosanLevofloxacinNanoparticlesPolyestersAnimalsAnti-Bacterial AgentsDrug CarriersDrug Delivery SystemsDrug LiberationParticle SizeSkinSkin AbsorptionTransdermal PatchAnti-Bacterial AgentsChitosanDrug CarriersLevofloxacinPolyesterspoly(lactide)drug releaselevofloxacinnanoencapsulationnanoneedlespoly(lactic acid) blendstransdermal delivery

Identifiers

PMID39339284
PMCPMC11433958

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.