Evidence map›Paper›PMID 39339247›Full record

ArticlePharmaceutics2024

Differential Effect of Simulated Microgravity on the Cellular Uptake of Small Molecules.

Odelia Tepper-Shimshon, Nino Tetro, Roa'a Hamed, Natalia Erenburg, Emmanuelle Merquiol, Gourab Dey, Agam Haim, Tali Dee, Noa Duvdevani, Talin Kevorkian and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Odelia Tepper-ShimshonInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0000-0002-4356-1604
Nino TetroInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Roa'a HamedInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0000-0002-4939-7171
Natalia ErenburgInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0009-0003-5909-5235
Emmanuelle MerquiolInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0000-0001-5754-498X
Gourab DeyInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.ORCID 0000-0002-9570-5032
Agam HaimSchool of Space Science, Hebrew University Youth Division, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Tali DeeSchool of Space Science, Hebrew University Youth Division, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Noa DuvdevaniSchool of Space Science, Hebrew University Youth Division, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Talin KevorkianSchool of Space Science, Hebrew University Youth Division, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Galia BlumInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Eylon YavinInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
Sara EyalInstitute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.

Funding

Israel Science Foundation 1366/23Israel Space Agency 0004079Israel Space Agency 0006055
6 · The paper itself

Abstract

The space environment can affect the function of all physiological systems, including the properties of cell membranes. Our goal in this study was to explore the effect of simulated microgravity (SMG) on the cellular uptake of small molecules based on reported microgravity-induced changes in membrane properties. SMG was applied to cultured cells using a random-positioning machine for up to three hours. We assessed the cellular accumulation of compounds representing substrates of uptake and efflux transporters, and of compounds not shown to be transported by membrane carriers. Exposure to SMG led to an increase of up to 60% (

Indexed as

BCRPbreast cancer resistance proteinGB123glucose transportersMDR1microgravityMRP1multidrug resistance–associated proteinsP-glycoproteinpharmacokinetics

Identifiers

PMID39339247
PMCPMC11435092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.