Evidence map›Paper›PMID 39339234›Full record

ArticlePharmaceutics2024

Assessing α-Bisabolol as a Transmucosal Permeation Enhancer of Buccal Local Anesthetics.

Renê Oliveira do Couto, Douglas Vieira Thomaz, Maira Perez Ferreira Duarte, Renata Fonseca Vianna Lopez, Vinícius Pedrazzi, Osvaldo de Freitas, Gianluca Martino Tartaglia

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chemical Profile and Bioinsecticidal Nanoemulsion ofPlants (Basel, Switzerland) · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Renê Oliveira do Couto"Dona Lindu" Midwest Campus, Universidade Federal de São João del-Rei (UFSJ), Divinopolis 35501-296, MG, Brazil.ORCID 0000-0002-3748-3427
Douglas Vieira ThomazDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, 20129 Milan, Italy.ORCID 0000-0003-0000-3466
Maira Perez Ferreira DuarteSchool of Pharmaceutical Sciences of Ribeirao Preto, Department of Pharmaceutical Sciences, Universidade de São Paulo (USP), Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0002-0385-6416
Renata Fonseca Vianna LopezSchool of Pharmaceutical Sciences of Ribeirao Preto, Department of Pharmaceutical Sciences, Universidade de São Paulo (USP), Ribeirão Preto 14040-900, SP, Brazil.ORCID 0000-0002-6448-6711
Vinícius PedrazziSchool of Dentistry of Ribeirao Preto, Department of Dental Materials and Prosthodontics, Universidade de São Paulo (USP), Ribeirão Preto 14040-904, SP, Brazil.ORCID 0000-0003-0701-6999
Osvaldo de FreitasSchool of Pharmaceutical Sciences of Ribeirao Preto, Department of Pharmaceutical Sciences, Universidade de São Paulo (USP), Ribeirão Preto 14040-900, SP, Brazil.
Gianluca Martino TartagliaDepartment of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, 20129 Milan, Italy.

Funding

Brazilian National Council for Scientific and Technological Development (CNPq) grant #480962/2013-8; project awards 472817/2012-4 and 429465/2016-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) 001Italian Ministry of Health Current Research IRCCSSão Paulo Research Foundation (FAPESP) grants 2012/05644-0 and 2013/ 12174-3; project awards 2012/06478-7 and 2014/22451-7
6 · The paper itself

Abstract

Needle-free buccal anesthesia improves dental treatment outcomes for both patients and dentists. In this study, we report on an assessment of the enhancement effects of α-bisabolol on the in vitro transmucosal permeation of prilocaine hydrochloride (PCl) and lidocaine hydrochloride (LCl) from needleless buccal films. We also evaluated the mechanical properties of the film, which consisted of Methocel™ K100 LV as the film-forming polymer (3% m·m

Indexed as

buccal drug administrationhypromellose derivativeslidocainelocal anesthesiaprilocaine drug combinationvolatile oil

Identifiers

PMID39339234
PMCPMC11434793

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.