Evidence map›Paper›PMID 39339213›Full record

ArticlePharmaceutics2024

Direct and Abscopal Antitumor Responses Elicited by AlPcNE-Mediated Photodynamic Therapy in a Murine Melanoma Model.

José Athayde Vasconcelos Morais, Pedro H A Barros, Marcelo de Macedo Brigido, Clara Luna Marina, Anamelia Bocca, André de Lima E Silva Mariano, Paulo E N de Souza, Karen L R Paiva, Marina Mesquita Simões, Sonia Nair Bao and 6 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Effect of Curcumin Pretreatment on the Susceptibility ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

José Athayde Vasconcelos MoraisLaboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia Ceilandia Sul, Brasilia 72220-275, DF, Brazil.ORCID 0000-0003-3067-4842
Pedro H A BarrosLaboratory of Molecular Immunology, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Marcelo de Macedo BrigidoLaboratory of Molecular Immunology, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-7136-7059
Clara Luna MarinaLaboratory of Applied Immunology, Institute of Biology Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-0819-0756
Anamelia BoccaLaboratory of Applied Immunology, Institute of Biology Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0003-3323-5300
André de Lima E Silva MarianoLaboratory for Softwares and Physics Instrumentation Development, Institute of Physics, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0001-8013-8250
Paulo E N de SouzaLaboratory for Softwares and Physics Instrumentation Development, Institute of Physics, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-4289-8678
Karen L R PaivaLaboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-2098-4401
Marina Mesquita SimõesLaboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-9814-5827
Sonia Nair BaoLaboratory of Microscopy and Microanalysis, Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-9873-3098
Luana C CamargoLaboratory of Nanoscience and Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-7223-037X
João P Figueiró LongoLaboratory of Nanoscience and Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-5154-7263
Amanda Alencar Cabral MoraisLaboratory of Nanoscience and Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-6974-0889
Ricardo B de AzevedoLaboratory of Nanoscience and Nanobiotechnology, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.ORCID 0000-0002-2137-9588
Marcio J P FonsecaLaboratory of Gene Regulation and Mutagenesis, Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil.
Luis A MuehlmannLaboratory of Nanoscience and Immunology, Faculty of Ceilandia, University of Brasilia Ceilandia Sul, Brasilia 72220-275, DF, Brazil.ORCID 0000-0003-4711-7583

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 01Fundação de Apoio à Pesquisa do Distrito Federal 00193.00001053/2021-24Fundação de Apoio à Pesquisa do Distrito Federal 0019300001531/2021-04National Council for Scientific and Technological Development (CNPq) 403536/2021-9
6 · The paper itself

Abstract

Melanoma, the most aggressive form of skin cancer, presents a major clinical challenge due to its tendency to metastasize and recalcitrance to traditional therapies. Despite advances in surgery, chemotherapy, and radiotherapy, the outlook for advanced melanoma remains bleak, reinforcing the urgent need for more effective treatments. Photodynamic therapy (PDT) has emerged as a promising alternative, leading to targeted tumor destruction with minimal harm to surrounding tissues. In this study, the direct and abscopal antitumor effects of PDT in a bilateral murine melanoma model were evaluated. Although only one of the two tumors was treated, effects were observed in both. Our findings revealed significant changes in systemic inflammation and alterations in CD4

Indexed as

cancerimmune systemimmunityimmunotherapynanoemulsiontranscriptome

Identifiers

PMID39339213
PMCPMC11435272

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.