Evidence map›Paper›PMID 39339203›Full record

ArticlePharmaceutics2024

Self-Assembled Nanoparticles of Silicon (IV)-NO Donor Phthalocyanine Conjugate for Tumor Photodynamic Therapy in Red Light.

Kadireya Aikelamu, Jingya Bai, Qian Zhang, Jiamin Huang, Mei Wang, Chunhong Zhong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kadireya AikelamuXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Jingya BaiXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Qian ZhangXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Jiamin HuangXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Mei WangXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.
Chunhong ZhongXinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, Ministry of Education, Engineering Research Center of Xinjiang and Central Asian Medicine Resources, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.

Funding

Autonomous Region Graduate Student Scientific Research Innovation Plan Project, China XJ2023G197Engineering Research Center of Xinjiang and Central Asian Medicine Resources, Ministry of Education, China Educational Science Letter [2023] No. 23Xinjiang Key Laboratory of Natural Medicines Active Components and Drug Release Technology, China XJDX1713
6 · The paper itself

Abstract

The combination of photodynamic therapy (PDT) and pneumatotherapy is emerging as one of the most effective strategies for increasing cancer treatment efficacy while minimizing side effects. Photodynamic forces affect nitric oxide (NO) levels as activated photosensitizers produce NO, and NO levels in the tumor and microenvironment directly impact tumor cell responsiveness to PDT. In this paper, 3-benzenesulfonyl-4-(1-hydroxy ether)-1,2,5-oxadiazole-2-oxide NO donor-silicon phthalocyanine coupling (SiPc-NO) was designed and prepared into self-assembled nanoparticles (SiPc-NO@NPs) by precipitation method. By further introducing arginyl-glycyl-aspartic acid (RGD) on the surface of nanoparticles, NO-photosensitizer delivery systems (SiPc-NO@RGD NPs) with photo-responsive and tumor-targeting properties were finally prepared and preliminarily evaluated in terms of their formulation properties, NO release, and photosensitizing effects. Furthermore, high reactive oxygen species (ROS) generation efficiency and high PDT efficiency in two breast cancer cell lines (human MCF-7 and mouse 4T1) under irradiation were also demonstrated. The novel SiPc-NO@RGD NPs show great potential for application in NO delivery and two-photon bioimaging-guided photodynamic tumor therapy.

Indexed as

nitric oxidephotosensitizerself-assembled nanoparticles

Identifiers

PMID39339203
PMCPMC11435187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.