Evidence map›Paper›PMID 39339075›Full record

ArticlePolymers2024

Melatonin and Bacterial Cellulose Regulate the Expression of Inflammatory Cytokines, VEGF, PCNA, and Collagen in Cutaneous Wound Healing in Diabetic Rats.

Jaiurte Gomes Martins da Silva, Ismaela Maria Ferreira de Melo, Érique Ricardo Alves, Glícia Maria de Oliveira, Anderson Arnaldo da Silva, Isabela Macário Ferro Cavalcanti, Diego Neves Araujo, Flávia Cristina Morone Pinto, José Lamartine de Andrade Aguiar, Valéria Wanderley Teixeira and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jaiurte Gomes Martins da SilvaGraduate Program of Animal Bioscience, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil.ORCID 0000-0002-6310-1023
Ismaela Maria Ferreira de MeloGraduate Program of Animal Bioscience, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil.ORCID 0000-0002-4150-1923
Érique Ricardo AlvesGraduate Program of Animal Bioscience, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil.
Glícia Maria de OliveiraGraduate Program of Therapeutic Innovation, Department of Biochemistry, Federal University of Pernambuco, Recife 50170-901, PE, Brazil.
Anderson Arnaldo da SilvaGraduate Program in Biosciences and Biotechnology in Health, Oswaldo Cruz Foundation, Federal University of Pernambuco, Recife 50170-901, PE, Brazil.
Isabela Macário Ferro CavalcantiLaboratory of Clinical Microbiology, Keizo Asami Institute (iLIKA), Federal University of Pernambuco (UFPE), Recife 50170-901, PE, Brazil.ORCID 0000-0002-7889-3502
Diego Neves AraujoDepartment of Medicine, Federal University of Alagoas, Arapiraca 57309-005, AL, Brazil.ORCID 0000-0002-9541-5852
Flávia Cristina Morone PintoGraduate Program of Surgery, Department of Surgery, Federal University of Pernambuco, Recife 50170-901, PE, Brazil.
José Lamartine de Andrade AguiarGraduate Program of Surgery, Department of Surgery, Federal University of Pernambuco, Recife 50170-901, PE, Brazil.ORCID 0000-0003-4493-7359
Valéria Wanderley TeixeiraGraduate Program of Animal Bioscience, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil.
Álvaro Aguiar Coelho TeixeiraGraduate Program of Animal Bioscience, Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco, Recife 52171-900, PE, Brazil.

Funding

This work was carried out with the support of Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brazil (CAPES) 88887.611499/2021-00
6 · The paper itself

Abstract

The poor healing of diabetic wounds is characterized by prolonged inflammation and decreased collagen deposition. Diabetic patients exhibit changes in the plasma concentrations of pro-inflammatory cytokines, and the role of specific dressings may have an impact on healing. This study aims to evaluate the effects of a combined treatment comprising a bacterial cellulose dressing and melatonin application on the regulation and expression of inflammatory cytokines, VEGF, PCNA, and collagen in the healing of cutaneous wounds of diabetic rats. Pro-inflammatory cytokines, including IL-6, TNF-α, and VEGF, along with PCNA and type I and III collagen, were evaluated after 14 days. Immunohistochemistry showed decreased levels of IL-6, TNF-α, and VEGF, along with an increased expression of PCNA and type I collagen, in the groups treated exclusively with melatonin and bacterial cellulose associated with melatonin compared to the control and the commercial healing agent. It was concluded that treating the skin lesions of diabetic animals supplemented with melatonin using a bacterial cellulose-based dressing has positive effects in regulating the expression of inflammatory cytokines, vascular endothelial growth factor, and collagen, showing that this association could be a viable therapy approach in wound healing.

Indexed as

dressingsinflammationpinealstreptozotocin

Identifiers

PMID39339075
PMCPMC11435683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.