ArticlePathogens (Basel, Switzerland)2024
Evaluation of 16S-Based Metagenomic NGS as Diagnostic Tool in Different Types of Culture-Negative Infections.
Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- From Gut Commensal to Opportunistic Pathogen: A Narrative Review ofAntibiotics (Basel, Switzerland) · 2026Review
- Metagenomic Profile of Bacterial Communities ofPathogens (Basel, Switzerland) · 2025Article
- QIIME2 enhances multi-amplicon sequencing data analysis: a standardized and validated open-source pipeline for comprehensive 16S rRNA gene profiling.Microbiology spectrum · 2025Article
- The complex diagnosis of post-dialysis fever: a case report and literature review of infective endocarditis in a dialysis patient.BMC nephrology · 2025Review
- Challenging case of bacterial meningitis due toQatar medical journal · 2025Article
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Authors and funding
11 authors.
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Abstract
Bacterial infections pose significant global health challenges, often underestimated due to difficulties in accurate diagnosis, especially when culture-based diagnostics fail. This study assesses the effectiveness of 16S-based metagenomic next generation sequencing (NGS) for identifying pathogens in culture-negative clinical samples across various medical settings. Overall, 48% of samples were collected from orthopedics, 15% from neurosurgery, and 12% in cardiac surgery, among others. The detection rate of monomicrobial infections was 68.6%, and 5.7% for polymicrobial infections. In addition, NGS detected bacteria in all samples from the lungs, head and neck, and eye specimens.
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