Evidence map›Paper›PMID 39338927›Full record

ArticlePathogens (Basel, Switzerland)2024

Estimating the Seroprevalence of Scrub Typhus in Nepal.

Piyada Linsuwanon, Nutthanun Auysawasdi, Chien-Chung Chao, Wuttikon Rodkvamtook, Binob Shrestha, Samita Bajracharya, Jasmin Shrestha, Sirima Wongwairot, Chawin Limsuwan, Erica Lindroth and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Piyada LinsuwanonDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Nutthanun AuysawasdiDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Chien-Chung ChaoNaval Medical Research Command, Silver Spring, MD 10400, USA.
Wuttikon RodkvamtookAnalysis Division, Royal Thai Army-Armed Forces Research Institute of Medical Science, Bangkok 10400, Thailand.
Binob ShresthaWalter Reed/AFRIMS Research Unit Nepal, Kathmandu 44600, Nepal.
Samita BajracharyaWalter Reed/AFRIMS Research Unit Nepal, Kathmandu 44600, Nepal.
Jasmin ShresthaWalter Reed/AFRIMS Research Unit Nepal, Kathmandu 44600, Nepal.ORCID 0000-0003-3989-0744
Sirima WongwairotDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Chawin LimsuwanDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Erica LindrothDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Alyssa MannDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Silas DavidsonDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Elizabeth WanjaDepartment of Entomology, Walter Reed Army Institute of Research-Armed Forces Research Institute of Medical Science (AFRIMS), Bangkok 10330, Thailand.
Sanjaya Kumar ShresthaWalter Reed/AFRIMS Research Unit Nepal, Kathmandu 44600, Nepal.

Funding

Department of Entomology, USAMD-AFRIMS 17_AF_1.5.2 AND P0081_18_AF_05.03
6 · The paper itself

Abstract

Prior to the devastating earthquake in Nepal in 2015, scrub typhus was not recognized as a highly endemic disease in the country. This contrasted with neighboring India, where scrub typhus is endemic and there have been sporadic outbreaks of severe forms. This discrepancy underscores the limitations in our comprehensive understanding of the scrub typhus epidemiological patterns in Nepal, especially before 2015. To better understand the dynamic and current status of scrub typhus, this study investigated its prevalence among patients with acute febrile illness in two hospitals located in Pokhara city, Kaski district and Bharatpur city, Chitwan district during 2009-2010. Our findings revealed that 31.5% (239 of 759 patients) of the cases were positives for scrub typhus based on serological and pathogen detection assays. These results provide crucial insights into the pre-earthquake endemicity of scrub typhus in Nepal, implying its long-standing presence in the region prior to the significant environmental transformations caused by the 2015 earthquake. This study also emphasizes the need for heightened awareness and improved diagnostic capabilities to effectively manage and control scrub typhus, which remains a significant public health concern in Nepal.

Indexed as

Orientia tsutsugamushiScrub TyphusAdolescentAdultAgedAntibodies, BacterialChildChild, PreschoolFemaleHumansMaleMiddle AgedNepalPrevalenceSeroepidemiologic StudiesYoung AdultAntibodies, Bacterialacute febrile illnessNepalOrientia tsutsugamushirecombinant protein ELISAscrub typhusserosurveillance

Identifiers

PMID39338927
PMCPMC11435068

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.